A new series of triazolothiadiazines as potential anticancer agents for targeted therapy of non-small cell lung and colorectal cancers: design, synthesis, in silico and in …
Background: Targeted therapies acting on specific molecular targets in cancer cells with
better curative efficacy and lower toxicity have come into prominence for the management of …
better curative efficacy and lower toxicity have come into prominence for the management of …
The Assessment of Anticancer and VEGFR-2 Inhibitory Activities of a New 1H-Indole Derivative: In Silico and In Vitro Approaches
Corresponding to the reported features of anti-VEGFR-2-approved compounds, a new 1 H-
indole derivative (compound 7) was designed. The inhibitory potential of the designed …
indole derivative (compound 7) was designed. The inhibitory potential of the designed …
Synthesis of [1, 2, 4] triazolo [3, 4-b][1, 3, 4] thiadiazine-1, 2, 3-triazoles as potent EGFR targeting anti-breast cancer agents
Synthetic chemists have organized easy and effective ways for perfect synthesis in response
to the requirement for scaffolds that are crucial for medical applications. A general strategy …
to the requirement for scaffolds that are crucial for medical applications. A general strategy …
In-silico identification of small molecule benzofuran-1, 2, 3-triazole hybrids as potential inhibitors targeting EGFR in lung cancer via ligand-based pharmacophore …
Lung cancer is one of the most common and deadly types of cancer worldwide, and the
epidermal growth factor receptor (EGFR) has emerged as a promising therapeutic target for …
epidermal growth factor receptor (EGFR) has emerged as a promising therapeutic target for …
Antitumor activity, multitarget mechanisms, and molecular docking studies of quinazoline derivatives based on a benzenesulfonamide scaffold: Cell cycle analysis
The in vitro cytotoxicity of some substituted quinazolinones, 1–15, was evaluated using NCI
(10 µM) in a full NCI 59–cell line panel assay. Relative to the reference drug, imatinib (PCE …
(10 µM) in a full NCI 59–cell line panel assay. Relative to the reference drug, imatinib (PCE …
New thiazolidine-2, 4-diones as potential anticancer agents and apoptotic inducers targeting VEGFR-2 kinase: Design, synthesis, in silico and in vitro studies
Background VEGFR-2 has emerged as a prominent positive regulator of cancer
progression. Aim Discovery of new anticancer agents and apoptotic inducers targeting …
progression. Aim Discovery of new anticancer agents and apoptotic inducers targeting …
Development of Novel Class of Phenylpyrazolo[3,4-d]pyrimidine-Based Analogs with Potent Anticancer Activity and Multitarget Enzyme Inhibition Supported by …
AKB Aljohani, WAZ El Zaloa, M Alswah… - International journal of …, 2023 - mdpi.com
Phenylpyrazolo [3, 4-d] pyrimidine is considered a milestone scaffold known to possess
various biological activities such as antiparasitic, antifungal, antimicrobial, and …
various biological activities such as antiparasitic, antifungal, antimicrobial, and …
Targeting EGFR tyrosine kinase: Synthesis, in vitro antitumor evaluation, and molecular modeling studies of benzothiazole-based derivatives
New benzothiazole-based derivatives were synthesized in the present work with the aim of
evaluating their antitumor activity. They were in vitro tested against hepatocellular carcinoma …
evaluating their antitumor activity. They were in vitro tested against hepatocellular carcinoma …
Novel series of benzo [d] thiazolyl substituted-2-quinolone hybrids: Design, synthesis, biological evaluation and in-silico insights
Abstract A novel series of 3-(2-(4-(substituted-benzo [d] thiazol-2-yl) phenylamino) acetyl)-4‑
hydroxy-1-methyl/phenyl quinolin-2 (1H)-one (7a-f and 8a-f) were synthesized. Reaction of …
hydroxy-1-methyl/phenyl quinolin-2 (1H)-one (7a-f and 8a-f) were synthesized. Reaction of …
Design, synthesis, molecular docking, and anticancer evaluation of pyrazole linked pyrazoline derivatives with carbothioamide tail as EGFR kinase inhibitors
Background: The Epidermal Growth Factor Receptor (known as EGFR) induces cell
differentiation and proliferation upon activation through the binding of its ligands. Since …
differentiation and proliferation upon activation through the binding of its ligands. Since …