New Thiazolyl-Pyrazoline derivatives as potential dual EGFR/HER2 inhibitors: design, synthesis, anticancer activity evaluation and in silico study
A new series of thiazolyl-pyrazoline derivatives (4a–d, 5a–d 6a, b, 7a–d, 8a, b, and 10a, b)
have been designed and synthesized through the combination of thiazole and pyrazoline …
have been designed and synthesized through the combination of thiazole and pyrazoline …
Semi-synthesized anticancer theobromine derivatives targeting VEGFR-2: in silico and in vitro evaluations
Vascular endothelial cell proliferation and angiogenesis are all crucially impacted by
Endothelial Growth Factor Receptor-2 (VEGFR-2). Its expression is significantly boosted …
Endothelial Growth Factor Receptor-2 (VEGFR-2). Its expression is significantly boosted …
Synthesis and biological evaluation of novel [1, 2, 3] triazolo-pyrrolo [1, 2-a] pyrido [4, 3-d] pyrimidines as EGFR targeting anticancer agents
SR Bandi, N Kavitha, SK Nukala… - Journal of Molecular …, 2023 - Elsevier
Herein, we synthesized some new fused [1, 2, 3] triazolo-pyrrolo [1, 2-a] pyrido [4, 3-d]
pyrimidines via click chemistry followed by carbon-carbon bond coupling as key approach …
pyrimidines via click chemistry followed by carbon-carbon bond coupling as key approach …
New Thiazole Derivatives Linked to Pyridine, Fused Pyridine, Pyrimidine and Thiazolopyrimidine Scaffolds with Potential Dual Anticancer and Antimicrobial Activities …
ZM Alamshany, ES Nossier - Journal of Molecular Structure, 2024 - Elsevier
The present study involved the design and synthesis of a novel series of thiazole derivatives
3, 5, 7, 8, 10–13 having various heterocyclic scaffolds, including pyrazole, pyridine, and/or …
3, 5, 7, 8, 10–13 having various heterocyclic scaffolds, including pyrazole, pyridine, and/or …
New thiazole-based derivatives as EGFR/HER2 and DHFR inhibitors: Synthesis, molecular modeling simulations and anticancer activity
New series of thiazole and imidazo [2, 1-b] thiazole derivatives were synthesized and tested
for their in vitro anticancer activity. Compounds 27, 34, 39 and 42–44 showed the best …
for their in vitro anticancer activity. Compounds 27, 34, 39 and 42–44 showed the best …
Unveiling the anticancer mechanism of 1, 2, 3-triazole-incorporated thiazole-pyrimidine-isoxazoles: insights from docking and molecular dynamics simulations
R Sireesha, Y Pavani, BD Mallavarapu… - Journal of …, 2023 - Taylor & Francis
Cancer is a major global health concern, and the constant search for novel, selective
anticancer compounds with low toxicity is never ending. Nitrogen heterocyclic compounds …
anticancer compounds with low toxicity is never ending. Nitrogen heterocyclic compounds …
Design and synthesis of new quinoline-ester/-amide derivatives as potent antiproliferative agent targeting EGFR and BRAFV600E kinases
AM Mohassab, HA Hassan, HA Abou-Zied… - Journal of Molecular …, 2024 - Elsevier
New quinoline-based derivatives 3a-d and 4a-d have been designed and synthesized as
promising antiproliferative candidates. The designed compounds were tested for their …
promising antiproliferative candidates. The designed compounds were tested for their …
Five and six membered heterocyclic rings endowed with azobenzene as dual EGFR T790M and VEGFR-2 inhibitors: design, synthesis, in silico ADMET profile …
KE Anwer, SSA El-Hddad, NEA Abd El-Sattar… - RSC …, 2023 - pubs.rsc.org
Novel azobenzene scaffold-joined heterocyclic isoxazole, pyrazole, triazole, and/or triazine
moieties have been developed and synthesized utilizing microwave and traditional …
moieties have been developed and synthesized utilizing microwave and traditional …
New series of benzothiazole and pyrimido[2,1-b]benzothiazole derivatives: synthesis, antitumor activity, EGFR tyrosine kinase inhibitory activity and molecular …
MT Gabr, NS El-Gohary, ER El-Bendary… - Medicinal Chemistry …, 2015 - Springer
New series of benzothiazole and pyrimido [2, 1-b] benzothiazole derivatives were
synthesized and characterized by analytical and spectrometrical methods (IR, HRMS, 1 H …
synthesized and characterized by analytical and spectrometrical methods (IR, HRMS, 1 H …
Imidazo [1, 2-a] quinazolines as novel, potent EGFR-TK inhibitors: Design, synthesis, bioactivity evaluation, and in silico studies
Z Hasanvand, TO Bakhshaiesh, F Peytam… - Bioorganic …, 2023 - Elsevier
Tyrosine protein kinases (TKs) have been proved to play substantial roles on many cellular
processes and their overexpression tend to be found in various types of cancers. Therefore …
processes and their overexpression tend to be found in various types of cancers. Therefore …