[HTML][HTML] Design, synthesis, and biological evaluation of new pyrimidine-5-carbonitrile derivatives as novel anti-cancer, dual EGFR WT/COX-2 inhibitors with docking …
A novel series of pyrimidine-5-carbonitrile derivatives was designed, synthesized, then
evaluated for their cytotoxic activity as novel anti-cancer with dual EGFRWT/COX-2 …
evaluated for their cytotoxic activity as novel anti-cancer with dual EGFRWT/COX-2 …
Design, synthesis, and mechanistic insight of novel imidazolones as potential EGFR inhibitors and apoptosis inducers
FG Abdulrahman, HS Abulkhair, HS El Saeed… - Bioorganic …, 2024 - Elsevier
As regards to the structural analysis and optimization of diverse potential EGFR inhibitors,
two series of imidazolyl-2-cyanoprop-2-enimidothioates and ethyl …
two series of imidazolyl-2-cyanoprop-2-enimidothioates and ethyl …
[PDF][PDF] Designing, molecular docking, and dynamics simulations studies of 1, 2, 3-triazole clamped Uracil-Coumarin hybrids against EGFR tyrosine kinase
Since the last decade, hybrid drug strategies have attracted many researchers for their
improved anti-cancer potential in comparison to single drug components. Complying to this …
improved anti-cancer potential in comparison to single drug components. Complying to this …
In vitro Anticancer and Insilico Studies of Quinoxaline‐sulfonyl‐1, 2, 4‐triazole Hybrids
G Dasari, S Bandari, S Kumar Nukala… - …, 2022 - Wiley Online Library
Abstract New quinoxaline‐sulfonyl‐1, 2, 4‐triazole hybrids were synthesized (5 a–n) via
systematic step‐wise sequence. Later, the in vitro cytotoxicity screening of all these …
systematic step‐wise sequence. Later, the in vitro cytotoxicity screening of all these …
[HTML][HTML] New oxadiazole and pyrazoline derivatives as anti-proliferative agents targeting EGFR-TK: design, synthesis, biological evaluation and molecular docking …
Two new series of oxadiazole and pyrazoline derivatives were designed and synthesized as
promising EGFR-TK inhibitors. The in vitro antiproliferative activity was studied against three …
promising EGFR-TK inhibitors. The in vitro antiproliferative activity was studied against three …
[HTML][HTML] Design, synthesis, computational study and cytotoxic evaluation of some new quinazoline derivatives containing pyrimidine moiety
Quinazoline derivatives, as an important category of heterocyclic compounds, have received
much attention for the design and development of new drugs due to their various …
much attention for the design and development of new drugs due to their various …
[HTML][HTML] 1, 5-benzothiazepine derivatives: green synthesis, in silico and in vitro evaluation as anticancer agents
Considering the importance of benzothiazepine pharmacophore, an attempt was carried out
to synthesize novel 1, 5-benzothiazepine derivatives using polyethylene glycol-400 (PEG …
to synthesize novel 1, 5-benzothiazepine derivatives using polyethylene glycol-400 (PEG …
Novel quinoline-3-carboxamides (Part 2): Design, optimization and synthesis of quinoline based scaffold as EGFR inhibitors with potent anticancer activity
RM Aly, RAT Serya, AM El-Motwally, A Esmat… - Bioorganic …, 2017 - Elsevier
EGFR has a key role in cell growth. Its mutation and overexpression share in epithelial
malignancies and tumor growth. Quinazoline and quinoline derivatives are common …
malignancies and tumor growth. Quinazoline and quinoline derivatives are common …
Design and synthesis of thiazolidine-2, 4-diones hybrids with 1, 2-dihydroquinolones and 2-oxindoles as potential VEGFR-2 inhibitors: In-vitro anticancer evaluation …
Abstract A thiazolidine-2, 4-dione nucleus was molecularly hybridised with the effective
antitumor moieties; 2-oxo-1, 2-dihydroquinoline and 2-oxoindoline to obtain new hybrids …
antitumor moieties; 2-oxo-1, 2-dihydroquinoline and 2-oxoindoline to obtain new hybrids …
Tetrahydrobenzothiophene derivatives ameliorate Mia PaCa-2 cell progression and induces apoptosis via inhibiting EGFR2 tyrosine kinase signal
A series of new thiophene analogues with a carbonitrile-based moiety were designed and
synthesized via structural optimization. The conjugates were assessed for their in-vitro …
synthesized via structural optimization. The conjugates were assessed for their in-vitro …