Design, synthesis, computational study and cytotoxic evaluation of some new quinazoline derivatives containing pyrimidine moiety
S Zare, L Emami, Z Faghih, F Zargari, Z Faghih… - Scientific reports, 2023 - nature.com
Quinazoline derivatives, as an important category of heterocyclic compounds, have received
much attention for the design and development of new drugs due to their various …
much attention for the design and development of new drugs due to their various …
1, 5-benzothiazepine derivatives: green synthesis, in silico and in vitro evaluation as anticancer agents
M Haroun, SS Chobe, RR Alavala, SM Mathure… - Molecules, 2022 - mdpi.com
Considering the importance of benzothiazepine pharmacophore, an attempt was carried out
to synthesize novel 1, 5-benzothiazepine derivatives using polyethylene glycol-400 (PEG …
to synthesize novel 1, 5-benzothiazepine derivatives using polyethylene glycol-400 (PEG …
Design, synthesis, and docking studies of quinazoline analogues bearing aryl semicarbazone scaffolds as potent EGFR inhibitors
Y Tu, C Wang, S Xu, Z Lan, W Li, J Han, Y Zhou… - Bioorganic & medicinal …, 2017 - Elsevier
Two series of quinazoline derivatives bearing aryl semicarbazone scaffolds (9a–o and 10a–
o) were designed, synthesized and evaluated for the IC 50 values against four cancer cell …
o) were designed, synthesized and evaluated for the IC 50 values against four cancer cell …
Design and synthesis of thiazolidine-2, 4-diones hybrids with 1, 2-dihydroquinolones and 2-oxindoles as potential VEGFR-2 inhibitors: In-vitro anticancer evaluation …
MS Taghour, H Elkady, WM Eldehna… - Journal of Enzyme …, 2022 - Taylor & Francis
Abstract A thiazolidine-2, 4-dione nucleus was molecularly hybridised with the effective
antitumor moieties; 2-oxo-1, 2-dihydroquinoline and 2-oxoindoline to obtain new hybrids …
antitumor moieties; 2-oxo-1, 2-dihydroquinoline and 2-oxoindoline to obtain new hybrids …
New pyrimidine-5-carbonitrile derivatives as EGFR inhibitors with anticancer and apoptotic activities: design, molecular modeling and synthesis
IA Osman, RR Ayyad, HA Mahdy - New Journal of Chemistry, 2022 - pubs.rsc.org
In connection with our efforts in the development of new anticancer agents, herein we report
the design and synthesis of new small pyrimidine-5-carbonitrile based derivatives. The …
the design and synthesis of new small pyrimidine-5-carbonitrile based derivatives. The …
Targeting EGFR by Newer 1-(3, 5-Bis ((E)-4-hydroxy-3-methoxystyryl)-1H-pyrazol-1-yl)-2-((substituted phenyl) amino) ethan-1-one Analogues for the Treatment of …
MA Mohamed, A Ali, A Ali, O Afzal, MF Ahsan… - Journal of Molecular …, 2024 - Elsevier
Several curcumin analogues (C01-C03) were prepared in green solvent (water-glycerol; 2: 1
v/v) with boric acid (10% mol solution in glycerol). All the compounds were characterized by …
v/v) with boric acid (10% mol solution in glycerol). All the compounds were characterized by …
Synthesis, molecular docking and evaluation of thiazolyl-pyrazoline derivatives containing benzodioxole as potential anticancer agents
HH Wang, KM Qiu, HE Cui, YS Yang, M Xing… - Bioorganic & medicinal …, 2013 - Elsevier
A series of novel thiazolyl-pyrazoline derivatives containing benzodioxole (C1–C20) have
been designed and synthesized. Among of the synthesized compounds, 2-(5-(benzo [d][1, 3] …
been designed and synthesized. Among of the synthesized compounds, 2-(5-(benzo [d][1, 3] …
Novel quinoline-3-carboxamides (Part 2): Design, optimization and synthesis of quinoline based scaffold as EGFR inhibitors with potent anticancer activity
RM Aly, RAT Serya, AM El-Motwally, A Esmat… - Bioorganic …, 2017 - Elsevier
EGFR has a key role in cell growth. Its mutation and overexpression share in epithelial
malignancies and tumor growth. Quinazoline and quinoline derivatives are common …
malignancies and tumor growth. Quinazoline and quinoline derivatives are common …
Synthesis of novel pyrido [2, 3-d] pyrimidine-thiazolidine-1, 2, 3-triazoles: Potent EGFR targeting anticancer agents
SR Bandi, R Kapavarapu, R Palabindela… - Journal of Molecular …, 2023 - Elsevier
In this study, we designed and synthesized a number of novel pyrido [2, 3-d] pyrimidine-
thiazolidine-1, 2, 3-triazole derivatives and investigated them in vitro for their inhibitory …
thiazolidine-1, 2, 3-triazole derivatives and investigated them in vitro for their inhibitory …
Pharmacophore-based virtual screening approaches to identify novel molecular candidates against EGFR through comprehensive computational approaches and in …
FADM Opo, M Moulay, A Zari, A Alqaderi… - Frontiers in …, 2022 - frontiersin.org
Alterations to the EGFR (epidermal growth factor receptor) gene, which primarily occur in the
axon 18–21 position, have been linked to a variety of cancers, including ovarian, breast …
axon 18–21 position, have been linked to a variety of cancers, including ovarian, breast …