Intra-articular injection of glucocorticoids is used to relieve pain and inflammation in
osteoarthritis patients, which is occasionally accompanied with the serious side effects of …

Osteoarthritis (OA) is a common degenerative joint disease characterized by an imbalance
of cartilage extracellular matrix (ECM) breakdown and anabolism. Melatonin (MT) is one of …

Cartilage, a flexible and smooth connective tissue that envelops the surfaces of synovial
joints, relies on chondrocytes for extracellular matrix (ECM) production and the maintenance …

Reactive oxygen species (ROS) are implicated in induction of inflammatory response and
cartilage degradation in osteoarthritis (OA). Melatonin has been shown to improve the …

Melatonin has potent antioxidant, analgesic, and antinociceptive properties. However, the
effects of melatonin against oxidative stress‐induced cytotoxicity and inflammatory …

Recent evidence indicates that the mitochondrial functions of chondrocytes are impaired in
the pathogenesis of osteoarthritis (OA). Melatonin can attenuate cartilage degradation …

Osteoarthritis (OA) is a degenerative joint disease mainly characterized by cartilage
degradation. Interleukin-1β (IL-1β) contributes to OA pathogenesis by enhancing oxidative …

Objective To observe the effect of melatonin intervention on rat knee osteoarthritis (KOA)
model and explore its mechanism. Methods A total of 81 Sprague–Dawley (SD) rats were …

Osteoarthritis (OA) is characterized by the progressive destruction of articular cartilage,
which is involved in the imbalance between extracellular matrix (ECM) synthesis and …

Cartilage is a relatively simple connective tissue that plays a variety of roles in the human
body, including joint support and protection, load bearing of the intervertebral discs, joint …