The present study was designed to detect DNA repair response through the homologous
recombination pathway in mouse spermatogonial stem cells. Mouse spermatogonial stem …

Homologous recombination (HR) is established as a significant contributor to double‐strand
break (DSB) repair in mammalian somatic cells; however, its role in mammalian germ cells …

The present study aims to examine the effect of low-dose ionizing irradiation on DNA double
strand breaks (DSB) in mouse spermatogonial stem cells (SSCs) and reveal the underlying …

Abstract 53BP1 mediates DNA repair process in somatic cells; however, the function of
53BP1 in germline stem cells still remains unclear. In the present study, animals and cells …

This study was designed to obtain a better insight into the relative contribution of
homologous recombination (HR) and non-homologous end joining (NHEJ) to the repair of …

Spermatogenesis is a complex developmental process. During this process, male germ cells
from spermatogonia to sperm cells encounter a number of DNA damages. The most severe …

Spermatogonial stem cells (SSCs) must maintain the integrity of their genome to prevent
reproduction failure and limit the hereditary risk associated with transmission to the progeny …

Sertoli cells isolated from the adult mouse and human testis resume proliferation in culture.
After 20 days of culture in Dulbecco modified Eagle medium/Ham F12 (DMEM/F12) medium …

Lifelong mammalian male fertility is maintained through an intricate balance between
spermatogonial proliferation and differentiation. DNA damage in spermatogonia, for …

Mammalian germ cells encounter several types of DNA damage. This damage is almost
completely repaired in a short period of time to provide the maintenance of genomic …