Spermatogonial stem cells (SSCs) are slowly dividing cells that undergo self-renewal
division to support spermatogenesis. Although the effects of genetic background in stem cell …

Mammalian spermatogenesis is a highly complex multi-step process sustained by a
population of mitotic germ cells with self-renewal potential known as spermatogonial stem …

Men with testicular failure, either primary or secondary, have been shown to be interested in
fertility preservation. Spermatogonial stem cell (SSC) transplantation is currently being …

Spermatogonial stem cells (SSCs) undergo self-renewal division to support
spermatogenesis. Although several positive regulators of SSC self-renewal have been …

DNA double-strand breaks (DSBs) are commonly appearing deleterious DNA damages,
which progressively increase in male germ cells during biological aging. There are two main …

Spermatids are extremely sensitive to genotoxic exposures since during spermiogenesis
only error-prone non homologous end joining (NHEJ) repair pathways are available. Hence …

Germline mutations underlie genetic diversity and species evolution. Previous studies have
assessed the theoretical mutation rates and spectra in germ cells mostly by analyzing …

Spermatogonial stem cells (SSCs) undergo self-renewal division and support
spermatogenesis. Although several cytokines coordinate to drive SSC self-renewal, little is …

Repair of SPO11-dependent DNA double-strand breaks (DSBs) via homologous
recombination (HR) is essential for stable homologous chromosome pairing and synapsis …

Spermatogonial transplantation provides a straightforward approach to quantify
spermatogonial stem cells (SSCs). Because donor-derived spermatogenesis is regenerated …