Spermatogonial stem cells (SSCs) undergo self-renewal divisions to provide the foundation
for spermatogenesis. Although Rb1 deficiency is reportedly essential for SSC self-renewal …

Spermatogonial transplantation provides a straightforward approach to quantify
spermatogonial stem cells (SSCs). Because donor-derived spermatogenesis is regenerated …

In somatic cells, H2afx and Mdc1 are close functional partners in DNA repair and damage
response. However, it is not known whether they are also involved in the maintenance of …

A mammalian body is composed of more than 200 different types of cells. The purification of
a certain cell type from tissues/organs enables a wide variety of studies. One popular cell …

Stem cells in the male germ line (spermatogonial stem cells [SSCs]) are an important target
for male fertility restoration and germ line gene modification. To establish a model system to …

The repair of DNA double strand breaks (DSBs) in male germ cells is slower and differently
regulated compared to that in somatic cells. Round spermatids show DSB repair and are …

Human sperm cryopreservation for assisted reproduction is compromised by ROS-induced
sperm cryodamage. Our previous model study in which mouse sperm were treated with …

The purpose of this study was (i) To establish in vitro propagation of human spermatogonial
stem cells (hSSC s) from small testicular biopsies to obtain a high number of cells;(ii) to …

Spermatogonial stem cells (SSC) ensure continuous production of mammalian male
gametes. In rodents, the SSC are Asingle spermatogonia (As). Gene loss and gain-of …

Gonadotoxic therapies, particularly radiation and chemotherapy used in the treatment of
cancer, are extremely damaging to spermatogenesis. They may result in prolonged or …