During the intricate processes of replication and expression, DNA is susceptible to damage
from various exogenous and endogenous factors. Such damage can impact the formation of …

Spermatogonial stem cells (SSCs) represent a unique testicular cell type that has the
capacity for proliferating, differentiating, and transmitting genetic information. This particular …

Homologous recombination (HR) and nonhomologous end-joining (NHEJ) are
mechanistically distinct DNA repair pathways that contribute substantially to double-strand …

Aim: To investigate whether adriamycin induces DNA damage and the formation of γH2AX
(the phosphorylated form of histone H2AX) foci in mature spermatozoa. Methods: Human …

Fertility preservation for prepubertal cancer patients prior to oncologic treatment is an
emerging issue, and non‐human primates are considered to constitute suitable models due …

Somatic cell hybridization is widely used to study the control of gene regulation and the
stability of differentiated states. In contrast, the application of this method to germ cells has …

Spermatogonial stem cell (SSC) transplantation is a novel technique by which testicular
cells from normal, transgenic or mutant donor are introduced into the seminiferous tubules of …

We devised a sensitive method for the site-specific detection of rare meiotic DNA strand
breaks in germ cell-enriched testicular cell populations from mice that possess or lack an …

Spermatogonial stem cells (SSCs) are defined by their ability to both self-renew and
produce differentiated germ cells that will develop into functional spermatozoa. Because of …

Meiotic sex chromosome inactivation (MSCI) is an essential event in the mammalian male
germline. MSCI is directed by a DNA damage response (DDR) pathway centered on the …