Aim: To investigate whether adriamycin induces DNA damage and the formation of γH2AX
(the phosphorylated form of histone H2AX) foci in mature spermatozoa. Methods: Human …

We devised a sensitive method for the site-specific detection of rare meiotic DNA strand
breaks in germ cell-enriched testicular cell populations from mice that possess or lack an …

Spermatogonial stem cells (SSCs) are defined by their ability to both self-renew and
produce differentiated germ cells that will develop into functional spermatozoa. Because of …

Accumulated understanding of epigenetic modifications during ischemia‐reperfusion (IR)
injury suggests that additional targeted approaches and novel mechanisms that have not …

The development of techniques to maintain the spermatogonial stem cell (SSC) in vivo and
in vitro for extended periods essentially allows for the indefinite continuation of an individual …

In this issue of Biology of Reproduction, Kanatsu-Shinohara et al.[1] report a novel technique
for culturing spermatogonial stem cells (SSCs) in the absence of both serum and feeder …

Meiotic sex chromosome inactivation (MSCI) is an essential event in the mammalian male
germline. MSCI is directed by a DNA damage response (DDR) pathway centered on the …

Spermatogonial stem cells (SSCs) are the foundation for spermatogenesis and, thus,
preservation of a species. Because of stem cell rarity, studying their self-renewal is greatly …

Although stem cells are believed to divide infinitely by self-renewal division, there is little
evidence that demonstrates their infinite replicative potential. Spermatogonial stem cells are …

In mice, the occurrence of immunofluorescent foci for mismatch repair protein MLH1
correlates closely with the occurrence of crossovers, as detected genetically, and MLH1 foci …