Under steady-state conditions, aged neutrophils are removed from the circulation in bone
marrow, liver, and spleen, thereby maintaining myeloid cell homeostasis. The fate of these …

We argue that age-related changes in HSCs and in the hematopoietic system may not
entirely be due to a degenerative aging process, but are the result of developmental and …

From a holistic point of view, aging results from the cumulative erosion of the various
systems. Among these, the immune system is interconnected to the rest as immune cells are …

Beginning with the sixth decade of life, the human immune system undergoes dramatic
aging-related changes, which continuously progress to a state of immunosenescence. The …

Neutrophils play a key role in the elimination of pathogens. They are remarkably short-lived
with a circulating half life of 6–8h and hence are produced at a rate of 5× 10 10–10× 10 10 …

Whereas, neutrophils have long been considered to mainly function as efficient innate
immunity killers of micro-organisms at infected sites, they are now recognized to also be …

Understanding why we age and how that process can be delayed or reversed are topics that
have engaged both researchers and the general public [1]. From a scientific perspective …

Aging leads to numerous changes that affect all physiological systems of the body including
the immune system, causing greater susceptibility to infectious disease and contributing to …

The aging process is driven by a finite number of inter‐related mechanisms that ultimately
lead to the emergence of characteristic phenotypes, including increased susceptibility to …

Hematopoietic stem cells (HSCs) support haematopoiesis throughout life and give rise to the
whole variety of cells of the immune system. Developing in the early embryo, passing …