Lactic acidosis is a common finding in critically ill patients during severe sepsis/septic shock,
and a powerful predictor of mortality. Because of the knowledge that lactate is the end …

There is increasing evidence that sepsis is accompanied by a hypermetabolic state, with
enhanced glycolysis and hyperlactataemia. This should not be rigorously interpreted as an …

Increased blood lactate concentration (hyperlactatemia) and lactic acidosis (hyperlactatemia
and serum pH< 7.35) are common in patients with severe sepsis or septic shock and are …

Conclusion An increased blood lactate concentration is clearly a marker for circulatory
failure and tissue hypoxia, including that associated with sepsis. Whether other mechanisms …

Purpose: This article reviews the current body of knowledge regarding lactic acidosis in
critically ill patients. The classification of disordered lactate metabolism and its pathogenesis …

Lactic acidosis is a metabolic derangement associated with a variety of pathologic states.
Since the most common etiology is circulatory shock, lactic acidosis serves as an important …

The processes that lead to increased blood lactate concentration in shock and critical illness
are complex. Although it is widely believed that lactic acidosis develops because of tissue …

An understanding of the pathophysiology of lactic acidosis is crucial in facilitating the optimal
care of critically ill patients. The relevant biochemistry of lactic acidosis is reviewed, and the …

Background The development of lactic acidosis in septic patients is an ominous event. Blood
lactate concentrations> 5 mM at the time of admission to the intensive care unit are …

Objective: To review the mechanisms of metabolic acidosis in sepsis. Data sources: Articles
and published reviews on metabolic acidosis in sepsis. Summary of review: Sepsis affects …