Genetic alterations of Ikaros family zinc finger protein 1 (IKZF 1), point mutations in Janus
kinase 2 (JAK 2), and overexpression of cytokine receptor‐like factor 2 (CRLF 2) were …

Background Genome‐wide analysis studies have demonstrated that IKZF1, CRLF2, and
JAK2 gene alterations correlate with poor prognosis in pediatric B‐cell precursor acute …

Deletions in IKZF1 are found in~ 15% of children with B-cell precursor acute lymphoblastic
leukemia (BCP-ALL). There is strong evidence for the poor prognosis of IKZF1 deletions …

This study aimed to investigate the combined impact of IKZF1 deletions/high expression of
CRLF2 on the prognosis of pediatric B-cell precursor acute lymphoblastic leukemia (BCP …

Purpose Somatic deletions that affect the lymphoid transcription factor–coding gene IKZF1
have previously been reported as independently associated with a poor prognosis in …

In contrast to IKZF1 deletions (ΔIKZF1), IKZF1 sequence mutations (mutIKZF1) have been
reported to be rare in B‐cell precursor acute lymphoblastic leukemia and their clinical …

IKZF1 gene deletions have been associated with a poor outcome in pediatric precursor B-
cell acute lymphoblastic leukemia. To assess the prognostic relevance of IKZF1 deletions for …

Background IKZF1 gene deletion is an indicator of poor prognosis in childhood B‐cell
precursor acute lymphoblastic leukemia (BCP‐ALL). The AEIOP/BFM group proposed that …

Despite current risk‐directed therapy, approximately 15–20% of pediatric patients with acute
lymphoblastic leukemia (ALL) have relapses. Recent genome‐wide analyses have …

Abstract Cytokine Receptor-Like Factor 2 (CRLF2) overexpression occurs in 5-15% of B-cell
precursor acute lymphoblastic leukaemia (B-ALL). In∼ 50% of these cases, the mechanisms …