Sickle cell disease (SCD) is a serious and life-threatening disease that affects approximately
1 in 600 African Americans [1, 2]. In 1910, Herrick described the first patient with SCD, and …

Sickle cell disease results in significant morbidity and mortality for those affected with this
disease. Despite the fact that every case of sickle cell disease results from the same genetic …

Sickle cell disease (SCD) is the name for a group of genetic blood disorders caused by
sickle hemoglobin (Hb S). The 2 key features of SCD are chronic hemolytic anemia and …

As more children are appropriately being diagnosed, the burden of sickle cell disease is
increasing greatly in Africa and in high-resource countries such as the United States and …

This article summarizes my presentation at the Pediatric Hematology‐Oncology Symposium
in honor of Dr. Stephen A. Feig in April 2005. Areas highlighted reflect key topics whose …

From their basic genetic and molecular mechanisms to their clinical expression, the sickle
cell hemoglobinopathies are among the best understood of human diseases. However …

Sickle cell disease (SCD) is a single gene disorder causing a debilitating systemic
syndrome characterised by chronic anaemia, acute painful episodes, organ infarction and …

Treatment advances over the past 25 years have significantly decreased morbidity and
mortality in children with sickle cell disease. Aggressive management of fever, early …

The World Health Organization estimates that 7% of the world's population carries a
hemoglobin (Hgb) mutation and that 300,000 to 500,000 children are born each year with …

Thirty years ago, the first major federal legislation concerning sickle cell disease treatment
was passed, resulting in the development of comprehensive sickle cell centers. We are now …