Nitric oxide (nitrogen monoxide, NO) at low concentrations can potently deenergize isolated
liver and brain mitochondria at oxygen concentrations that prevail in cells and tissues …

We have recently shown (Schweizer, M., and Richter, C.(1994) Biochem. Biophys. Res.
Commun. 204, 169-175) that nitric oxide (nitrogen monoxide, NO) at low concentrations …

To elucidate the role of nitric oxide (NO) in the regulation of mitochondrial function, the effect
of NO on energy transfer reactions was examined under different oxygen tensions …

Nitric oxide (NO) inhibited the respiration rate of mitochondria isolated from rat heart at sub-
micromolar concentrations of NO. The inhibition was rapidly and completely reversible …

Nitric oxide (NO) reversibly inhibits mitochondrial respiration by competing with oxygen at
cytochrome oxidase. Concentrations of NO measured in a range of biological systems are …

Nitric oxide (NO) is produced in mam‐mals by different isoforms of NO synthase (NOS), in‐
cluding the constitutive mitochondrial enzyme (mtNOS). Here we demonstrate that the …

Nitric oxide (NO) and its derivative peroxynitrite (ONOO−) inhibit mitochondrial respiration by
distinct mechanisms. Low (nanomolar) concentrations of NO specifically inhibit cytochrome …

This article reviews the interactions between nitric oxide (NO) and mitochondrial respiration.
Mitochondrial ATP synthesis is responsible for virtually all energy production in mammals …

Nitric oxide (NO) and peroxynitrite both inhibit respiration by brain submitochondrial
particles, the former reversibly at cytochrome c oxidase, the latter irreversibly at complexes I …

Although the regulation of mitochondrial respiration and energy production in mammalian
tissues has been exhaustively studied and extensively reviewed, a clear understanding of …