Pain pharmacology in migraine: focus on CGRP and CGRP receptors
Over the last 100 years, the discovery of new analgesics has been a complex and difficult
task. However, remarkable progress in the identification of novel molecular targets relevant …
task. However, remarkable progress in the identification of novel molecular targets relevant …
Calcitonin gene‐related peptide (CGRP) is a key molecule released in acute migraine attacks—Successful translation of basic science to clinical practice
L Edvinsson - Journal of Internal Medicine, 2022 - Wiley Online Library
Migraine is a highly prevalent neurovascular disorder afflicting more than 15% of the global
population. Nearly three times more females are afflicted by migraine in the 18–50 years …
population. Nearly three times more females are afflicted by migraine in the 18–50 years …
CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond
Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …
CGRP as a neuropeptide in migraine: lessons from mice
AF Russo - British journal of clinical pharmacology, 2015 - Wiley Online Library
Migraine is a neurological disorder that is far more than just a bad headache. A hallmark of
migraine is altered sensory perception. A likely contributor to this altered perception is the …
migraine is altered sensory perception. A likely contributor to this altered perception is the …
CGRP monoclonal antibodies for migraine: rationale and progress
Calcitonin gene-related peptide (CGRP), a neuropeptide abundant in the trigeminal system
and widely expressed in both the peripheral and central nervous systems, has recently …
and widely expressed in both the peripheral and central nervous systems, has recently …
Calcitonin gene-related peptide: an update on the biology
A Recober, AF Russo - Current opinion in neurology, 2009 - journals.lww.com
The advent of CGRP receptor antagonists as a novel therapy for migraine attacks may
represent a new era in the acute management of migraine. More than a simple addition to …
represent a new era in the acute management of migraine. More than a simple addition to …
CGRP-based migraine therapeutics: how might they work, why so safe, and what next?
AF Russo - ACS pharmacology & translational science, 2018 - ACS Publications
Migraine is a debilitating neurological condition that involves the neuropeptide calcitonin
gene-related peptide (CGRP). An exciting development is the recent FDA approval of the …
gene-related peptide (CGRP). An exciting development is the recent FDA approval of the …
Calcitonin gene-related peptide in migraine: intersection of peripheral inflammation and central modulation
AC Raddant, AF Russo - Expert reviews in molecular medicine, 2011 - cambridge.org
Over the past two decades, a convergence of basic and clinical evidence has established
the neuropeptide calcitonin-gene-related peptide (CGRP) as a key player in migraine …
the neuropeptide calcitonin-gene-related peptide (CGRP) as a key player in migraine …
CGRP receptor antagonists: toward a novel migraine therapy
CA Salvatore, SA Kane - Current pharmaceutical …, 2011 - ingentaconnect.com
Migraine remains one of the most prevalent and disabling neurological disorders that often
affects a person during their most productive years. Migraine afflicts approximately 11% of …
affects a person during their most productive years. Migraine afflicts approximately 11% of …
Calcitonin gene-related peptide antagonists and therapeutic antibodies
RM Rujan, CA Reynolds - Calcitonin Gene-Related Peptide (CGRP) …, 2019 - Springer
The calcitonin gene-related peptide (CGRP) receptor is composed of the calcitonin receptor-
like receptor (CLR, a class B GPCR) and a single-pass membrane protein known as …
like receptor (CLR, a class B GPCR) and a single-pass membrane protein known as …