Over the last 100 years, the discovery of new analgesics has been a complex and difficult
task. However, remarkable progress in the identification of novel molecular targets relevant …

Migraine is a highly prevalent neurovascular disorder afflicting more than 15% of the global
population. Nearly three times more females are afflicted by migraine in the 18–50 years …

Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …

Migraine is a neurological disorder that is far more than just a bad headache. A hallmark of
migraine is altered sensory perception. A likely contributor to this altered perception is the …

Calcitonin gene-related peptide (CGRP), a neuropeptide abundant in the trigeminal system
and widely expressed in both the peripheral and central nervous systems, has recently …

Migraine is a debilitating neurological condition that involves the neuropeptide calcitonin
gene-related peptide (CGRP). An exciting development is the recent FDA approval of the …

Migraine remains one of the most prevalent and disabling neurological disorders that often
affects a person during their most productive years. Migraine afflicts approximately 11% of …

Several lines of evidence pointed to an important role for CGRP in migraine. These included
the anatomic colocalization of CGRP and its receptor in sensory fibers innervating pain …

The calcitonin gene-related peptide (CGRP) receptor is composed of the calcitonin receptor-
like receptor (CLR, a class B GPCR) and a single-pass membrane protein known as …

The advent of CGRP receptor antagonists as a novel therapy for migraine attacks may
represent a new era in the acute management of migraine. More than a simple addition to …