Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity.
P Ten Dijke, H Ichijo, P Franzen, P Schulz, J Saras… - Oncogene, 1993 - europepmc.org
Human cDNA clones encoding four novel putative transmembrane protein serine/threonine
kinases, denoted activin receptor-like kinase (ALK)-1,-2,-3 and-4, were obtained using a …
kinases, denoted activin receptor-like kinase (ALK)-1,-2,-3 and-4, were obtained using a …
Cloning and characterization of a transmembrane serine kinase that acts as an activin type I receptor.
K Tsuchida, LS Mathews… - Proceedings of the …, 1993 - National Acad Sciences
Activin type II receptors are transmembrane protein-serine/threonine kinases. By using a
reverse-transcription PCR assay to screen for protein kinase sequences, we isolated a …
reverse-transcription PCR assay to screen for protein kinase sequences, we isolated a …
Formation and activation by phosphorylation of activin receptor complexes.
SA Willis, CM Zimmerman, LI Li… - Molecular …, 1996 - academic.oup.com
Activin is a protein growth and differentiation factor that initiates intracellular events through
the activation of a complex of transmembrane protein serine kinases. Two subfamilies of …
the activation of a complex of transmembrane protein serine kinases. Two subfamilies of …
Characterization of type I receptors for transforming growth factor-β and activin
P Ten Dijke, H Yamashita, H Ichijo, P Franzén, M Laiho… - Science, 1994 - science.org
Transforming growth factor-β (TGF-β) and activin exert their effects by binding to heteromeric
complexes of type I and type II receptors. The type II receptors for TGF-β and activin are …
complexes of type I and type II receptors. The type II receptors for TGF-β and activin are …
Novel activin receptors: distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors
L Attisano, JL Wrana, S Cheifetz, J Massague - Cell, 1992 - cell.com
We have cloned ActR-IIB, which encodes four new activin receptor isoforms belonging to the
protein serinel threonine kinase receptor family. Two of the ActR-IIB isoforms have higher …
protein serinel threonine kinase receptor family. Two of the ActR-IIB isoforms have higher …
Characterization of type II activin receptors. Binding, processing, and phosphorylation.
LS Mathews, WW Vale - Journal of Biological Chemistry, 1993 - ASBMB
Activins bind to two classes of cell surface proteins, type I receptors of approximately 50-55
kDa and type II receptors of approximately 70-75 kDa. The two cloned type II activin …
kDa and type II receptors of approximately 70-75 kDa. The two cloned type II activin …
Activation of signalling by the activin receptor complex
L Attisano, JL Wrana, E Montalvo… - Molecular and cellular …, 1996 - Am Soc Microbiol
Activin exerts its effects by simultaneously binding to two types of protein serine/threonine
kinase receptors, each type existing in various isoforms. Using the ActR-IB and ActR-IIB …
kinase receptors, each type existing in various isoforms. Using the ActR-IB and ActR-IIB …
A widely expressed transmembrane serine/threonine kinase that does not bind activin, inhibin, transforming growth factor beta, or bone morphogenic factor
K Matsuzaki, J Xu, F Wang, WL McKeehan… - Journal of Biological …, 1993 - ASBMB
Molecular cloning of complementary DNAs (cDNA) whose expression products bind activin
and transforming growth factor beta (TGF-beta 1 and-beta 2) suggests that transmembrane …
and transforming growth factor beta (TGF-beta 1 and-beta 2) suggests that transmembrane …
Activin receptors and cellular signaling by the receptor serine kinase family
LS Mathews - Endocrine reviews, 1994 - academic.oup.com
AN EMERGING theme in cell signaling research is the multifunctional nature of many growth
factors and cytokines. Proteins purified based on distinct activities are often found to have …
factors and cytokines. Proteins purified based on distinct activities are often found to have …
Molecular cloning and binding properties of the human type II activin receptor
CJ Donaldson, LS Mathews, WW Vale - Biochemical and Biophysical …, 1992 - Elsevier
A full-length cDNA for the type II human activin receptor was cloned by hybridization from a
human testis cDNA library. The sequence encodes a 513 amino acid protein that is 99 …
human testis cDNA library. The sequence encodes a 513 amino acid protein that is 99 …