Human cDNA clones encoding four novel putative transmembrane protein serine/threonine
kinases, denoted activin receptor-like kinase (ALK)-1,-2,-3 and-4, were obtained using a …

Activin type II receptors are transmembrane protein-serine/threonine kinases. By using a
reverse-transcription PCR assay to screen for protein kinase sequences, we isolated a …

Activin is a protein growth and differentiation factor that initiates intracellular events through
the activation of a complex of transmembrane protein serine kinases. Two subfamilies of …

Transforming growth factor-β (TGF-β) and activin exert their effects by binding to heteromeric
complexes of type I and type II receptors. The type II receptors for TGF-β and activin are …

We have cloned ActR-IIB, which encodes four new activin receptor isoforms belonging to the
protein serinel threonine kinase receptor family. Two of the ActR-IIB isoforms have higher …

Activins bind to two classes of cell surface proteins, type I receptors of approximately 50-55
kDa and type II receptors of approximately 70-75 kDa. The two cloned type II activin …

Activin exerts its effects by simultaneously binding to two types of protein serine/threonine
kinase receptors, each type existing in various isoforms. Using the ActR-IB and ActR-IIB …

Molecular cloning of complementary DNAs (cDNA) whose expression products bind activin
and transforming growth factor beta (TGF-beta 1 and-beta 2) suggests that transmembrane …

AN EMERGING theme in cell signaling research is the multifunctional nature of many growth
factors and cytokines. Proteins purified based on distinct activities are often found to have …

A full-length cDNA for the type II human activin receptor was cloned by hybridization from a
human testis cDNA library. The sequence encodes a 513 amino acid protein that is 99 …