Reduced levels of high-density lipoprotein cholesterol (HDL) are associated with a
substantially increased risk of coronary disease and cardiovascular events. Furthermore …

Prospective population studies in the primary prevention setting have shown that reduced
plasma levels of HDL cholesterol are associated with an increased risk of coronary disease …

It is well recognised that increased levels of high density lipoprotein (HDL) protect against
atherosclerosis and correlate with improved prognosis for vascular disease associated …

The formation of the atherosclerotic plaque that is characterized by the accumulation of
abnormal amounts of cholesterol-loaded macrophages in the artery wall is mediated by both …

Observational studies provide overwhelming evidence that a low high-density lipoprotein
(HDL)–cholesterol level increases the risk of coronary events, both in healthy subjects and …

Low high‐density lipoprotein (HDL)‐cholesterol levels are associated with an increased risk
of coronary artery disease (CAD) and myocardial infarction, which has triggered the …

In major statin trials, the relative risk reduction is typically in the range 25-35%, thus
indicating that the majority of cardiac events continues to occur despite statin therapy …

The risk of atherosclerosis is inversely related to circulating levels of high density lipoprotein
(HDL) cholesterol. Notably, in large-scale epidemiologic studies, this association is …

Recent studies involving HDL-raising therapeutics have greatly changed our understanding
of this field. Despite effectively raising HDL-C levels, niacin remains of uncertain clinical …

Hypercholesterolemia is one of the main risk factors for the development of atherosclerosis.
Among the various lipoprotein classes, however, high density lipoproteins (HDL) are …