The C3 transferases from Clostridium botulinum (C3bot) and Clostridium limosum (C3lim)
mono‐ADP‐ribosylate and thereby inactivate RhoA,‐B and‐C of eukaryotic cells. Due to …

C3 protein toxins produced by Clostridium (C.) botulinum and C. limosum are mono-ADP-
ribosyltransferases, which specifically modify the GTPases Rho A/B/C in the cytosol of …

The C3 enzymes from Clostridium (C.) botulinum (C3bot) and Clostridium limosum (C3lim)
are single chain protein toxins of about 25 kDa that mono-ADP-ribosylate Rho-A,-B, and-C …

C3 from Clostridium botulinum (C3) specifically modifies Rho GTPases RhoA, RhoB, and
RhoC by mono-ADP-ribosylation. The confined substrate profile of C3 is the basis for its use …

C3-like exoenzymes are produced by various microorganism including Clostridium
botulinum (C3bot), Bacillus cereus and Staphylococcus aureus. C3bot is the prototype of C3 …

The C3 toxin produced by Clostridium botulinum (C3bot) catalyzes the mono-ADP-
ribosylation of the small GTPases Rho A, B and C, resulting in their inactivation. Recently, a …

C3-like toxins ADP-ribosylate and inactivate Rho GTPases. Seven C3-like ADP-
ribosyltransferases produced by Clostridium botulinum, Clostridium limosum, Bacillus …

Clostridium botulinum adenosine diphosphate (ADP)-ribosyltransferase C3 was the first
bacterial exoenzyme/toxin found to act on small guanosine triphosphate (GTP) ases of the …

Clostridium botulinum C3 exoenzyme (C3) selectively inactivates RhoA/B/C GTPases by
ADP-ribosylation. Based on this substrate specificity C3 is a well-established tool in cell …

The Clostridium botulinum C3 exoenzyme selectively ADP-ribosylates low molecular weight
GTP-binding proteins RhoA, B and C. This covalent modification inhibits Rho signaling …