Design, synthesis, molecular docking, and anticancer evaluations of 1‐benzylquinazoline‐2,4(1H,3H)‐dione bearing different moieties as VEGFR‐2 inhibitors
K El‐Adl, AGA El‐Helby, H Sakr… - Archiv der …, 2020 - Wiley Online Library
A novel series of 1‐benzylquinazoline‐2, 4 (1H, 3H)‐dione derivatives, 6a, b to 11a–e, was
designed, synthesized, and evaluated for their anticancer activity against HepG2, HCT‐116 …
designed, synthesized, and evaluated for their anticancer activity against HepG2, HCT‐116 …
Design, synthesis, molecular docking, anticancer evaluations, and in silico pharmacokinetic studies of novel 5‐[(4‐chloro/2, 4‐dichloro) benzylidene] thiazolidine‐2, 4 …
K El‐Adl, AGA El‐Helby, H Sakr, RR Ayyad… - Archiv der …, 2021 - Wiley Online Library
The anticancer activity of novel thiazolidine‐2, 4‐diones was evaluated against HepG2, HCT‐
116, and MCF‐7 cells. MCF‐7 was the most sensitive cell line to the cytotoxicity of the new …
116, and MCF‐7 cells. MCF‐7 was the most sensitive cell line to the cytotoxicity of the new …
5‐(4‐Methoxybenzylidene) thiazolidine‐2, 4‐dione‐derived VEGFR‐2 inhibitors: design, synthesis, molecular docking, and anticancer evaluations
Abstract A novel series of 5‐(4‐methoxybenzylidene) thiazolidine‐2, 4‐dione derivatives, 5a–
g and 7a–f, was designed, synthesized, and evaluated for their anticancer activity against …
g and 7a–f, was designed, synthesized, and evaluated for their anticancer activity against …
Pyridine‐derived VEGFR‐2 inhibitors: rational design, synthesis, anticancer evaluations, in silico ADMET profile, and molecular docking
NM Saleh, AAH Abdel‐Rahman, AM Omar… - Archiv der …, 2021 - Wiley Online Library
Abstract Novel pyridine‐derived compounds (5–19) were designed and synthesized, and
their anticancer activities were evaluated against HepG2 and MCF‐7 cells, targeting the …
their anticancer activities were evaluated against HepG2 and MCF‐7 cells, targeting the …
New quinoxaline-2 (1 H)-ones as potential VEGFR-2 inhibitors: Design, synthesis, molecular docking, ADMET profile and anti-proliferative evaluations
Eleven new quinoxaline derivatives were designed and synthesized as modified VEGFR-2
inhibitors of our previous work. The synthesized compounds were tested against three …
inhibitors of our previous work. The synthesized compounds were tested against three …
Design, synthesis, docking, ADMET profile, and anticancer evaluations of novel thiazolidine‐2, 4‐dione derivatives as VEGFR‐2 inhibitors
K El‐Adl, H Sakr, SSA El‐Hddad… - Archiv der …, 2021 - Wiley Online Library
The anticancer activity of novel thiazolidine‐2, 4‐diones was evaluated against HepG2, HCT‐
116, and MCF‐7 cells. Among the tested cancer cell lines, HCT‐116 was the most sensitive …
116, and MCF‐7 cells. Among the tested cancer cell lines, HCT‐116 was the most sensitive …
Benzoxazole/benzothiazole‐derived VEGFR‐2 inhibitors: design, synthesis, molecular docking, and anticancer evaluations
AGA El‐Helby, H Sakr, IH Eissa… - Archiv Der …, 2019 - Wiley Online Library
A novel series of benzoxazole/benzothiazole derivatives 4a–c–11a–e were designed,
synthesized, and evaluated for anticancer activity against HepG2, HCT‐116, and MCF‐7 …
synthesized, and evaluated for anticancer activity against HepG2, HCT‐116, and MCF‐7 …
Design, synthesis, molecular docking, and anticancer activity of benzoxazole derivatives as VEGFR‐2 inhibitors
AGA El‐Helby, H Sakr, IH Eissa… - Archiv der …, 2019 - Wiley Online Library
Novel series of benzoxazoles 4a‐f‐16 were designed, synthesized, and evaluated for
anticancer activity against HepG2, HCT‐116, and MCF‐7 cells. HCT‐116 was the most …
anticancer activity against HepG2, HCT‐116, and MCF‐7 cells. HCT‐116 was the most …
Design, synthesis, and cytotoxic evaluation of certain 7‐chloro‐4‐(piperazin‐1‐yl) quinoline derivatives as VEGFR‐II inhibitors
MN Aboul‐Enein, AMAES El‐Azzouny… - Archiv der …, 2017 - Wiley Online Library
Signaling pathway inhibition of VEGFR‐II is visualized as valuable tool in cancer
management. In the current study, the synthesis of novel 1‐4‐(7‐chloroquinolin‐4‐yl) …
management. In the current study, the synthesis of novel 1‐4‐(7‐chloroquinolin‐4‐yl) …
Design, synthesis, molecular docking, and anticancer activity of phthalazine derivatives as VEGFR‐2 inhibitors
AGA El‐Helby, RRA Ayyad, H Sakr… - Archiv der …, 2017 - Wiley Online Library
Novel series of phthalazine derivatives 6–11 were designed, synthesized, and evaluated for
their anticancer activity against two human tumor cell lines, HCT‐116 human colon …
their anticancer activity against two human tumor cell lines, HCT‐116 human colon …