PURPOSE: A small proportion of patients with chronic myeloid leukemia (CML) achieve a
complete cytogenetic response (CCR), defined as the disappearance of Philadelphia (Ph) …

A substantial minority of patients with chronic myelogenous leukemia (CML) achieve a
complete response (CR) to treatment with interferon-(IFN), defined as the disappearance …

PURPOSE Interferon alfa (IFN-alpha) induces complete cytogenetic remission in a
significant minority of patients with chronic myelogenous leukemia (CML). To date, use of …

BACKGROUND Little is known regarding long‐term prognosis among patients with
Philadelphia chromosome (Ph)‐positive chronic myelogenous leukemia (CML) who achieve …

Fig 1. Cumulative incidence of MCR among the 47 evaluable patients (cumulative
incidences and cytogenetic responses were analyzed by the Kaplan and Meier method and …

The objective of this study was to investigate the prognostic impact of the reduction of
Philadelphia chromosome (Ph) positive metaphases by treatment of chronic myelogenous …

Achieving a complete cytogenetic response (CCgR) is a major target in the treatment of
chronic myeloid leukemia (CML) with interferon-α (IFN-α), but CCgRs are rare. The mean …

Interferon (IFN) therapy has become widely used for the treatment of chronic myelogenous
leukemia. Hematologic remissions can be induced in about 60% of patients. Moreover, in a …

PURPOSE To investigate whether cytogenetic clonal evolution can be suppressed with
interferon alfa (IFN-alpha) therapy in patients with chronic myelogenous leukemia (CML) …

131 patients with Philadelphia (Ph') chromosome positive chronic myelogenous leukemia
(CML) were treated with interferon (IFN) alpha or a combination of IFN alpha and IFN …