Switching between biologics in severe asthma patients. When the first choice is not proven to be the best
AI Papaioannou, E Fouka, D Papakosta… - Clinical & …, 2021 - Wiley Online Library
During the last decades, new treatments targeting disease mechanisms referred as
biologics have been introduced in the therapy of asthma and currently, five monoclonal …
biologics have been introduced in the therapy of asthma and currently, five monoclonal …
Biologics in severe asthma: the overlap endotype-opportunities and challenges
A Bakakos, S Loukides, OS Usmani… - Expert Opinion on …, 2020 - Taylor & Francis
Introduction Patients with severe asthma experience a significant burden of symptoms,
disease exacerbations and medication side-effects. Severe asthma interferes with the …
disease exacerbations and medication side-effects. Severe asthma interferes with the …
Biologics in asthma: difficulties and drawbacks
J Bousquet, R Chiron, M Humbert - Expert opinion on biological …, 2008 - Taylor & Francis
Background: Biologics have become an increasingly important class of therapeutic
compounds in a variety of immune and/or inflammatory diseases. Patients with severe …
compounds in a variety of immune and/or inflammatory diseases. Patients with severe …
The evolving algorithm of biological selection in severe asthma
New therapeutic options for severe asthma have recently emerged, mostly in the form of
monoclonal antibodies (“biologicals”) targeting relevant inflammatory pathways. Currently …
monoclonal antibodies (“biologicals”) targeting relevant inflammatory pathways. Currently …
Biologics for severe asthma: treatment-specific effects are important in choosing a specific agent
JG Krings, MC McGregor, LB Bacharier… - The Journal of Allergy and …, 2019 - Elsevier
Patients with uncontrolled severe persistent asthma have greater morbidity, greater use of
health care resources, and more impairment in health-related quality of life when compared …
health care resources, and more impairment in health-related quality of life when compared …
Biologics in asthma—the next step toward personalized treatment
J Darveaux, WW Busse - The Journal of Allergy and Clinical Immunology …, 2015 - Elsevier
Asthma is a multifaceted disease and is associated with significant impairment and risk, and
a therapeutic response that is highly variable. Although current treatments are usually …
a therapeutic response that is highly variable. Although current treatments are usually …
How to compare the efficacy of biologic agents in asthma
RK Viswanathan, WW Busse - Annals of Allergy, Asthma & Immunology, 2020 - Elsevier
Objective The use of biologics in severe asthma has made substantial strides in disease
management and fostered a personalized medicine approach; however, how, when, and …
management and fostered a personalized medicine approach; however, how, when, and …
Biologic targeted therapy in allergic asthma
JB Bice, E Leechawengwongs, A Montanaro - Annals of Allergy, Asthma & …, 2014 - Elsevier
Objective To review the structure, function, clinical utility, and safety of current biologic
targeted therapies being used for the treatment of asthma. Data Sources Medical literature …
targeted therapies being used for the treatment of asthma. Data Sources Medical literature …
Monoclonal antibodies in the management of asthma: Dead ends, current status and future perspectives
Patients with moderate-to-severe asthma may now be treated using a variety of monoclonal
antibodies that target key inflammatory cytokines involved in disease pathogenesis. Existing …
antibodies that target key inflammatory cytokines involved in disease pathogenesis. Existing …
Effectiveness of switching biologics for severe asthma patients in Japan: a single-center retrospective study
T Numata, J Araya, H Miyagawa, K Okuda… - Journal of Asthma …, 2021 - Taylor & Francis
Background In Japan, biologic therapy was initiated for patients with severe asthma in 2009.
In recent years, four biologics with different mechanisms of action have become available in …
In recent years, four biologics with different mechanisms of action have become available in …