Down syndrome (DS) is characterized by increased mortality rates, both during early and
later stages of life, and age‐specific mortality risk remains higher in adults with DS …

It has been clearly established that there is an increased incidence of early onset dementia
of the Alzheimer type (DAT) in people who have Down syndrome. There are variations in the …

A subset of aged individuals with Down syndrome (DS) exhibits the clinical features of
Alzheimer's disease (AD) but our ability to detect dementia in this population is hampered by …

SUMMARY A key challenge to adults with Down syndrome (DS) as they age is an increased
risk for cognitive decline, dementia, and Alzheimer disease (AD). In DS persons ranging …

Down syndrome is associated with increased mortality rates due to congenital cardiac
defects and leukemia early in life, and with Alzheimer's disease and a tendency toward …

Chromosome 21, triplicated in Down Syndrome, contains several genes that are thought to
play a critical role in the development of AD neuropathology. The overexpression of the …

Virtually all adults with Down syndrome (DS) show the neuropathological changes of
Alzheimer disease (AD) by the age of 40 years. This association is partially due to …

Down syndrome (DS) is the most common genetic cause of intellectual disability in children,
and the number of adults with DS reaching old age is increasing. By the age of 40years …

Introduction Microglial cells play an important role in the development of Alzheimer's
disease (AD). People with Down syndrome (DS) inevitably develop AD neuropathology …

Alzheimer's disease (AD) is a progressive dementing disorder, with distinct neuropathology,
that affects about 10% of people over 65 years of age. Down's syndrome (DS), a …