Serotonin or 5-hydroxytryptamine (5-HT) regulates a wide spectrum of human physiology
through the 5-HT receptor family. We report the crystal structures of the human 5-HT1B G …

Abstract Serotonin (5-hydroxytryptamine; 5-HT) receptors modulate a variety of physiological
processes ranging from perception, cognition and emotion to vascular and smooth muscle …

hydroxytryptamine (5-HT, also known as serotonin) regulates many physiological processes
through the 5-HT receptor family. Here we report the crystal structure of 5-HT1B subtype …

Serotonin receptors are important targets for established therapeutics and drug
development as they are expressed throughout the human body and play key roles in cell …

5-hydroxytryptamine (5-HT serotonin) is a neurotransmitter essential for a large number of
physiological processes including the regulation of vascular and non-vascular smooth …

Serotonin receptors are prevalent throughout the nervous system and the periphery, and
remain one of the most lucrative and promising drug discovery targets for disorders ranging …

Studies of the serotonin (5-HT) receptors have illustrated several important concepts in G-
protein-mediated signaling. These concepts include G-protein specificity and cellular …

Abstract Serotonin, or 5-hydroxytryptamine (5-HT), is an important neurotransmitter, that
activates the largest subtype family of G-protein-coupled receptors. Drugs that target 5 …

A comprehensive, state-of-the-art review of our current understanding of the molecular and
structural biology of 5-HT receptors and their potential use for drug discovery. The authors …

The serotonin (5-hydroxytryptamine, 5-HT) receptors have been divided into 7 subfamilies
by convention, 6 of which include 13 different genes for G-protein-coupled receptors. Those …