The roles of autophagy in cancer

CW Yun, SH Lee - International journal of molecular sciences, 2018 - mdpi.com
Autophagy is an intracellular degradative process that occurs under several stressful
conditions, including organelle damage, the presence of abnormal proteins, and nutrient …

The dual role of autophagy in cancer development and a therapeutic strategy for cancer by targeting autophagy

CW Yun, J Jeon, G Go, JH Lee, SH Lee - International journal of …, 2020 - mdpi.com
Autophagy is a delicate intracellular degradation process that occurs due to diverse stressful
conditions, including the accumulation of damaged proteins and organelles as well as …

Autophagy as a molecular target for cancer treatment

NM Kocaturk, Y Akkoc, C Kig, O Bayraktar… - European Journal of …, 2019 - Elsevier
Autophagy is an evolutionarily conserved catabolic mechanism, by which eukaryotic cells
recycle or degrades internal constituents through membrane-trafficking pathway. Thus …

[HTML][HTML] Autophagy regulation in cancer development and therapy

EJ White, V Martin, JL Liu, SR Klein, S Piya… - American journal of …, 2011 - ncbi.nlm.nih.gov
Autophagy is a cellular process to degrade long-lived or malfunctioning proteins and
obsolete or damaged organelles. It maintains cellular homeostasis and helps cells survive …

Is targeting autophagy mechanism in cancer a good approach? The possible double-edge sword effect

SM Lim, EA Mohamad Hanif, SF Chin - Cell & bioscience, 2021 - Springer
Autophagy is a conserved cellular process required to maintain homeostasis. The hallmark
of autophagy is the formation of a phagophore that engulfs cytosolic materials for …

Challenges and therapeutic opportunities of autophagy in cancer therapy

VR Silva, SP Neves, LS Santos, RB Dias, DP Bezerra - Cancers, 2020 - mdpi.com
Simple Summary Autophagy is a physiological process characterized by the degradation of
the cell components through lysosomes due to stimuli/stress. In this study, we review the …

Understanding the role of autophagy in cancer formation and progression is a real opportunity to treat and cure human cancers

S Patergnani, S Missiroli, G Morciano, M Perrone… - Cancers, 2021 - mdpi.com
Simple Summary The modulation of autophagy represents a potential therapeutic strategy
for cancer. More than one hundred clinical trials have been conducted or are ongoing to …

Inhibiting autophagy to prevent drug resistance and improve anti-tumor therapy

JAZ Ramirez, GG Romagnoli, R Kaneno - Life sciences, 2021 - Elsevier
Cytotoxic drugs remain the first-line option for cancer therapy but the development of drug-
resistance by tumor cells represents a primary obstacle for successful chemotherapy …

[HTML][HTML] Autophagy in cancer

X Zhi, Q Zhong - F1000prime reports, 2015 - ncbi.nlm.nih.gov
Autophagy is a catabolic degradation process in which cellular proteins and organelles are
engulfed by double-membrane autophagosomes and degraded in lysosomes. Autophagy …

Targeting cancer cells through autophagy for anticancer therapy

S Turcotte, AJ Giaccia - Current opinion in cell biology, 2010 - Elsevier
Autophagy is a cellular degradation process in which portions of the cell's cytoplasm and
organelles are sequestered in a double-membrane bound vesicle called an …