The current and future therapies for human osteosarcoma

JD Lamplot, S Denduluri, J Qin, R Li… - Current cancer …, 2013 - ingentaconnect.com
Osteosarcoma (OS) is the most common non-hematologic malignant tumor of bone in adults
and children. As sarcomas are more common in adolescents and young adults than most …

Current therapeutic strategies and novel approaches in osteosarcoma

K Ando, MF Heymann, V Stresing, K Mori, F Rédini… - Cancers, 2013 - mdpi.com
Osteosarcoma is the most frequent malignant primary bone tumor and a main cause of
cancer-related death in children and adolescents. Although long-term survival in localized …

Osteosarcoma treatment: state of the art

HT Ta, CR Dass, PFM Choong, DE Dunstan - Cancer and Metastasis …, 2009 - Springer
Osteosarcoma (OS) is a class of cancer originating from bone, mainly afflicting children or
young adults. It is the second highest cause of cancer-related death in these age groups …

Management of osteosarcoma

J Whelan, B Seddon, M Perisoglou - Current Treatment Options in …, 2006 - Springer
Opinion statement Improving cure rates for osteosarcoma continues to be a major challenge.
The clinical management of individual patients is exacting and requires a skilled …

Advancing therapy for osteosarcoma

J Gill, R Gorlick - Nature reviews Clinical oncology, 2021 - nature.com
Improving the survival of patients with osteosarcoma has long proved challenging, although
the treatment of this disease is on the precipice of advancement. The increasing feasibility of …

State-of-the-art, approved therapeutics for the pharmacological management of osteosarcoma

C Meazza, SD Asaftei - Expert Opinion on Pharmacotherapy, 2021 - Taylor & Francis
Introduction: Advances in the treatment of osteosarcoma (OS) came in the mid-1970s, when
adding chemotherapy to surgery significantly improved patient survival. OS outcomes have …

Osteosarcoma

HC Beird, SS Bielack, AM Flanagan, J Gill… - Nature reviews Disease …, 2022 - nature.com
Osteosarcoma is the most common primary malignant tumour of the bone. Osteosarcoma
incidence is bimodal, peaking at 18 and 60 years of age, and is slightly more common in …

New targets and approaches in osteosarcoma

J Gill, MK Ahluwalia, D Geller, R Gorlick - Pharmacology & therapeutics, 2013 - Elsevier
Osteosarcoma is the most common primary tumor of bone. Approximately 2/3 of patients
who present with localized osteosarcoma can be expected to be cured of their disease with …

Osteosarcoma: accelerating progress makes for a hopeful future

AJ Saraf, JM Fenger, RD Roberts - Frontiers in oncology, 2018 - frontiersin.org
Patients who develop osteosarcoma in 2017 receive treatment that remains essentially
unchanged since the 1970s. Outcomes likewise remain largely unimproved. Large …

Molecular pathogenesis and therapeutic strategies of human osteosarcoma

SK Denduluri, Z Wang, Z Yan, J Wang… - Journal of …, 2015 - pmc.ncbi.nlm.nih.gov
Osteosarcoma (OS) is a devastating illness with rapid rates of dissemination and a poor
overall prognosis, despite aggressive standard-of-care surgical techniques and combination …