Purpose To identify novel genomic regions of interest in acute myeloid leukemia (AML) with
complex karyotypes, we applied comparative genomic hybridization to microarrays (array …

Acute myeloid leukemia (AML) is characterized by molecular heterogeneity. As commonly
altered genomic regions point to candidate genes involved in leukemogenesis, we used …

BACKGROUND AND OBJECTIVES: Acute myeloid leukemia (AML) is a heterogeneous
group of diseases. Patients with a normal karyotype constitute the largest single group; …

Purpose In acute myeloid leukemia (AML), studies based on whole-genome sequencing
have shown genomic diversity within leukemic clones. The aim of this study was to address …

Acute myeloid leukemia (AML) is a heterogeneous group of genetically defined diseases.
Their classification is important with regard to prognosis and treatment. We performed …

Conventional cytogenetic analysis currently stratifies acute myelogenous leukaemia (AML)
into prognostically relevant groups. However, approximately 50% of adult AMLs have …

Acute myeloid leukemia (AML) with a complex aberrant karyotype is a distinct biological
entity. It is characterized by:(1) a sharp increase in incidence above age 50;(2) a …

Background In patients with acute myeloid leukemia (AML) a combination of methods must
be used to classify the disease, make therapeutic decisions, and determine the prognosis …

Over the last decades, significant advances have been made in the knowledge and
treatment of acute myeloid leukemia (AML). The WHO has recognized this new information …

Cytogenetic analysis of acute myeloid leukemia (AML) cells has accelerated the
identification of genes important for AML pathogenesis. To complement cytogenetic studies …