The endothelium plays a crucial role in the control of vascular homoeostasis through
maintaining the synthesis of the vasoprotective molecule NO•(nitric oxide). Endothelial …

The study of reactive oxygen species (ROS) and oxidative stress remains a very active area
of biological research, particularly in relation to cellular signaling and the role of ROS in …

Endothelial nitric oxide (NO) plays important roles in the vascular system. Animal models
that show vascular dysfunction demonstrate the protective role of endothelial NO dependent …

The cerebrovascular regulation involves highly complex mechanisms to assure that the
brain is perfused at all times. These mechanisms depend on all components of the …

Reactive oxygen species (ROS) are a diverse family of molecules generated by all cells.
ROS may serve as important cell-signalling molecules in the cerebral circulation. Indeed, in …

Nitric oxide (NO) produced by the endothelium of cerebral arterioles is an important
mediator of endothelium-dependent vasodilation (EDV), and also helps to prevent …

In 1980, Furchgott and Zawadski demonstrated the release of an endothelium-derived
relaxing factor (EDRF) in isolated rabbit aorta with exposure to acetylcholine (Furchgott and …

Endothelial dysfunction is a marker of atherosclerosis and contributes to the atherogenic
process and the development of atherothrombotic complications. Oxidative stress has been …

Endothelial dysfunction, intended as the complex multifaced pathological product of different
vasculotoxic agents or injuries, is viewed today as an attractant intermediate phenotype of …

ia-inducible factor-1α (Figure). 25, 26 Although relatively little is known regarding effects of
ROS on gene expression in vascular cells, examples of such effects are beginning to …