Malignant transformation and growth of the tumor mass tend to induce changes in the
surrounding microenvironment. Abnormality of the tumor microenvironment provides a …

Nano-sized therapeutic agents have several advantages over low molecular weight agents
such as a larger loading capacity, the ability to protect the payload until delivery, more …

Passive targeting is the foremost mechanism by which nanocarriers and drug-bearing
macromolecules deliver their payload selectively to solid tumors. An important driver of …

Tumor targeting by nanomedicine-based therapeutics has emerged as a promising
approach to overcome the lack of specificity of conventional chemotherapeutic agents and to …

Over recent years, advancements in nanomedicine have allowed new approaches to
diagnose and treat tumors. Nano drug delivery systems exploit the enhanced permeability …

Classic chemotherapy has little or no specificity for cancer cells, normally resulting in low
accumulation at the tumor region (inefficacy), and in severe side effects (toxicity). This …

The enhanced permeability and retention (EPR) of nanoparticles in tumors has long stood
as one of the fundamental principles of cancer drug delivery, holding the promise of safe …

Nanomedicines including liposomes, micelles, and nanoparticles based on the enhanced
permeability and retention (EPR) effect have become the mainstream for tumor treatment …

Anticancer drugs as well as nano-sized drug delivery systems face many barriers that hinder
penetration deeply and evenly into solid tumors: a chaotic, tortuous vascular compartment …

Enhanced permeability of the tumor vasculature allows macromolecules to enter the tumor
interstitial space, whereas the suppressed lymphatic filtration allows them to stay there. This …