In this study, Wareham and colleagues quantified the combined effects of genetic and
lifestyle factors on risk of T2D in order to inform strategies for prevention. The authors found …

Aims/hypothesis Studying gene–lifestyle interaction may help to identify lifestyle factors that
modify genetic susceptibility and uncover genetic loci exerting important subgroup effects …

The descriptive epidemiology of type 2 diabetes suggests that gene–lifestyle interactions are
critical to the development of the condition. However, unravelling the molecular detail of …

Aims/hypothesis We aimed to investigate whether the impact of obesity and unfavourable
lifestyle on type 2 diabetes risk is accentuated by genetic predisposition. Methods We …

Abstract Type 2 diabetes (T2D) is a global public health challenge. Whilst the advent of
genome-wide association studies has identified> 400 genetic variants associated with T2D …

Aims/hypothesis Although a family history of type 2 diabetes is a strong risk factor for the
disease, the factors mediating this excess risk are poorly understood. In the InterAct case …

The pathophysiological influence of gene‐lifestyle interactions on the risk to develop type 2
diabetes (T2D) is currently under intensive research. This systematic review summarizes the …

Type 2 diabetes (T2D) and obesity are complex disorders that constitute major public health
problems. The evidence for familial aggregation of both T2D and obesity is substantial. To …

Background Both genetic and lifestyle factors contribute to the risk of type 2 diabetes, but the
extent to which there is a synergistic effect of the 2 factors is unclear. The aim of this study …

Background Whether genetic susceptibility to type 2 diabetes is modified by a healthy
lifestyle among Chinese remains unknown. Objectives The aim of the study was to …