The differential effects of static compression and recovery from compression on biosynthesis
and biosynthetic pathways of aggrecan, link protein, and hyaluronan were assessed. During …

Data presented previously suggest that release of components of the cartilage matrix, in
response to catabolic agents, cannot be accounted for by proteolytic mechanisms alone. In …

Loading of articular cartilage during weight bearing is essential for the maintenance of
cartilage function. Although certain cyclic loading protocols stimulate extracellular matrix …

Previous studies have shown that static equilibrium compression of cartilage tissue in vivo
and in vitro decreases chondrocyte synthesis of aggrecan molecules. In order to identify …

The goal of this study was to examine the effects of mechanical compression on chondrocyte
biosynthesis of extracellular matrix (ECM) components during culture in a new alginate disk …

The goal of this study was to examine the simultaneous effects of mechanical compression
of chondrocytes on mRNA expression and macromolecular synthesis of aggrrecan and type …

The effects of mechanical compression of calf cartilage explants on the catabolism and loss
into the medium of proteoglycans and proteins radiolabeled with [35 S] sulfate and [3 H] …

The effects of short-and long-term load-controlled compression on the levels of aggrecan
mRNA have been determined. Results show that a compressive stress of 0.1 MPa on bovine …

In paired observations the in vitro proteoglycan turnover was studied of human normal and
osteoarthritic cartilage in the absence and presence of intermittent hydrostatic compressive …

Static and dynamic compression are known to modulate the metabolism of articular
cartilage. The present study focused on determining the effects of compressive loading on …