Novel ocular antihypertensive compounds in clinical trials

J Chen, SA Runyan, MR Robinson - Clinical ophthalmology, 2011 - Taylor & Francis
Introduction: Glaucoma is a multifactorial disease characterized by progressive optic nerve
injury and visual field defects. Elevated intraocular pressure (IOP) is the most widely …

Current and new pharmacotherapeutic approaches for glaucoma

WS Shalaby, V Shankar, R Razeghinejad… - Expert Opinion on …, 2020 - Taylor & Francis
Introduction Glaucoma is the leading cause of irreversible blindness worldwide. Medical
therapy is the main line of treatment of open-angle glaucoma (OAG) and ocular …

[HTML][HTML] Focus: drug development: novel pharmacologic candidates for treatment of primary open-angle glaucoma

LJ Lu, JC Tsai, J Liu - The Yale Journal of Biology and Medicine, 2017 - ncbi.nlm.nih.gov
Primary open-angle glaucoma (OAG) affects approximately 45 million people worldwide and
more than 2.5 million people aged 40 years or older in the United States. Pharmacologic …

Achieving low target pressures with today's glaucoma medications

L Cantor - Survey of ophthalmology, 2003 - Elsevier
In the 21st century there are more highly effective medical management options for
glaucoma than there were in the 1980s and 1990s. In deciding among them, the clinician's …

Pharmacotherapies for glaucoma

CB Toris - Current molecular medicine, 2010 - ingentaconnect.com
Glaucoma is a group of progressive optic neuropathies in which the axons in the optic nerve
are injured, retinal ganglion cell numbers are reduced and vision is gradually and …

Glaucoma management: relative value and place in therapy of available drug treatments

D Sambhara, AA Aref - Therapeutic advances in chronic …, 2014 - journals.sagepub.com
Lowering intraocular pressure (IOP) is the only proven therapeutic intervention for
glaucomatous optic neuropathy. Despite advances in laser and microsurgical techniques …

Current medical therapy and future trends in the management of glaucoma treatment

B Cvenkel, M Kolko - Journal of Ophthalmology, 2020 - Wiley Online Library
Glaucoma is a neurodegenerative disease characterized by progressive loss of retinal
ganglion cells and their axons. Lowering of intraocular pressure (IOP) is currently the only …

Identifying new drugs and targets to treat rapidly elevated intraocular pressure for angle closure and secondary glaucomas to curb visual impairment and prevent …

NA Sharif - Experimental eye research, 2023 - Elsevier
A multitude of pharmacological compounds have been shown to lower and control
intraocular pressure (IOP) in numerous species of animals and human subjects after topical …

[PDF][PDF] Does that drug work? Pitfalls in studies on the efficacy and safety of glaucoma medications

CB Camras, D Minckler - American Journal of Ophthalmology, 2000 - academia.edu
IN A PERFECT WORLD, THE EFFICACY OF THERAPEUTIC agents for glaucoma would be
determined through large, well-planned, randomized controlled trials (RCTs), placebo …

New classes of glaucoma medications

EM Schehlein, GD Novack… - Current opinion in …, 2017 - journals.lww.com
Although challenges in medical treatment of glaucoma exist, particularly in patient
adherence, medical therapy remains the first line treatment for almost all glaucoma patients …