Changing paradigms in the medical treatment of glaucoma

JB Soltau, TJ Zimmerman - Survey of Ophthalmology, 2002 - Elsevier
Glaucoma is defined by a typical optic neuropathy accompanied by characteristic visual field
loss and eventual blindness. The major risk factor for glaucoma is elevated intraocular …

Pharmacology of novel intraocular pressure-lowering targets that enhance conventional outflow facility: pitfalls, promises and what lies ahead?

G Prasanna, B Li, M Mogi, DS Rice - European Journal of Pharmacology, 2016 - Elsevier
Intraocular pressure (IOP) lowering drugs that are approved for the treatment of glaucoma
and ocular hypertension have limited activity on increasing aqueous humor movement …

Current and emerging medical therapies in the treatment of glaucoma

A Bagnis, M Papadia, R Scotto… - Expert opinion on …, 2011 - Taylor & Francis
Introduction: Glaucoma is a disease of the eye in which the optic nerve and retinal ganglion
cells (RGCs) are injured, leading to the loss of the peripheral visual field and eventually to …

Is there more to glaucoma treatment than lowering IOP?

M Mozaffarieh, J Flammer - Survey of ophthalmology, 2007 - Elsevier
Classic glaucoma treatment focuses on intraocular pressure (IOP) reduction. Better
knowledge of the pathogenesis of the disease has opened up new therapeutical …

Pharmacological advances in the treatment of glaucoma

JB Serle - Drugs & aging, 1994 - Springer
Glaucoma is a potentially blinding disease. The goal of glaucoma therapy is to reduce
intraocular pressure to a predetermined target level. There are currently 5 classes of …

Clinical options for the reduction of elevated intraocular pressure

L Crawley, SM Zamir, MF Cordeiro… - Ophthalmology and eye …, 2012 - journals.sagepub.com
Elevated IOP in clinical practice is usually seen in glaucoma or ocular hypertension.
Glaucoma affects 60 million people worldwide and 8.4 million are bilaterally blind from this …

[PDF][PDF] Current management of glaucoma and the need for complete therapy

SJ McKinnon, LD Goldberg, P Peeples, JG Walt… - Am J Manag Care, 2008 - aoa.org
Glaucoma is a long-term ocular neuropathy defined by optic disc or retinal nerve fiber
structural abnormalities and visual field abnormality. Primary open-angle glaucoma is the …

Update on the medical treatment of primary open-angle glaucoma

A Cheema, RT Chang, A Shrivastava… - The Asia-Pacific Journal …, 2016 - journals.lww.com
Glaucoma comprises a group of progressive, neurodegenerative disorders characterized by
retinal ganglion cell death and nerve fiber layer atrophy. Several randomized controlled …

Advances in the discovery of novel agents for the treatment of glaucoma

F Mincione, A Nocentini, CT Supuran - Expert Opinion on Drug …, 2021 - Taylor & Francis
Introduction Glaucoma, a neuropathy characterized by increased intraocular pressure (IOP),
is the major cause of blindness worldwide and its treatment aims at reducing IOP. Areas …

Medical treatment of glaucoma: present and future

P Fogagnolo, L Rossetti - Expert opinion on investigational drugs, 2011 - Taylor & Francis
Introduction: In the last decades, the therapy of glaucoma has largely shifted from surgery to
medical treatment thanks to the introduction of strongly effective formulations, that is …