Introduction Genome wide association studies, replicated by numerous well powered
validation studies, have revealed a large number of loci likely to play a role in susceptibility …

Introduction The objective was to study the potential genetic contribution of Toll-like receptor
(TLR) genes in rheumatoid arthritis (RA). TLRs bind to pathogen-associated molecular …

Introduction The T allele of a single nucleotide polymorphism (SNP: rs2544390) in
lipoprotein receptor-related protein 2 (LRP2) is associated with higher serum urate and risk …

Abstract Objectives. A missense SNP, C1858T, in PTPN22 has been identified as a genetic
risk factor for rheumatoid arthritis (RA). Subsequent work has suggested that other variants …

This study aims to determine the molecular mechanisms and analgesic effects of transient
receptor potential vanilloid 1 (TRPV1) in the treatments of osteoarthritis (OA) and rheumatoid …

There is increasing evidence that common genetic variants can contribute to general
immune dysregulation and susceptibility to noninfectious inflammatory diseases. The …

Introduction This study investigated five confirmed rheumatoid arthritis (RA) susceptibility
genes/loci (HLA-DRB1, PTPN22, STAT4, OLIG3/TNFAIP3 and TRAF1/C5) for association …

Objective. To evaluate the occurrence of variants of the interleukin 4 (IL‐4) and IL‐4 receptor
(IL‐4R) genes in patients with rheumatoid arthritis (RA) and their possible contribution to …

Objective The majority of cytokines and growth factors known to be involved in cartilage
metabolism are synthesized by the chondrocytes themselves. They are up‐regulated in …

Neuropathic pain-like joint symptoms (NP) are seen in a proportion of individuals diagnosed
with osteoarthritis (OA) and post total joint replacement (TJR). In this study, we performed a …