There is increasing evidence that common genetic variants can contribute to general
immune dysregulation and susceptibility to noninfectious inflammatory diseases. The …

Introduction This study investigated five confirmed rheumatoid arthritis (RA) susceptibility
genes/loci (HLA-DRB1, PTPN22, STAT4, OLIG3/TNFAIP3 and TRAF1/C5) for association …

Objective The majority of cytokines and growth factors known to be involved in cartilage
metabolism are synthesized by the chondrocytes themselves. They are up‐regulated in …

Objective. To evaluate the occurrence of variants of the interleukin 4 (IL‐4) and IL‐4 receptor
(IL‐4R) genes in patients with rheumatoid arthritis (RA) and their possible contribution to …

Neuropathic pain-like joint symptoms (NP) are seen in a proportion of individuals diagnosed
with osteoarthritis (OA) and post total joint replacement (TJR). In this study, we performed a …

OBJECTIVE: The vanilloid receptor transient receptor potential vanilloid 1 (TRPV1),
expressed by sensory neurons that innervate joints, is implicated in arthritis but the …

Introduction A candidate gene approach, in a large case–control association study in the
Dutch population, has shown that a 480 kb block on chromosome 4q27 encompassing …

Objective: To determine whether rheumatoid factor (RF), anti-cyclic citrullinated peptide
(CCP) antibodies, or carriage of shared epitope (SE) and PTPN22 genetic susceptibility …

Rheumatoid arthritis (RA) is a systemic autoimmune disease mainly characterized by
chronic inflammation of the synovial joints. Although the etiology of RA is largely unknown, a …

Genetic biomarkers could be useful for orienting treatment of patients with rheumatoid
arthritis (RA), but none has been convincingly validated yet. Putative biomarkers include 14 …