Variants of ALPK1 with ABCG2, SLC2A9, and SLC22A12 increased the positive predictive value for gout

HP Tu, A Min-Shan Ko, SS Lee, CP Lee… - Journal of human …, 2018 - nature.com
We investigated the interactions of ALPK1 variants and the loci of ABCG2, SLC2A9, and
SLC22A12 on gout risk. We conducted two case–control studies. Participants were recruited …

[HTML][HTML] ALPK1 genetic regulation and risk in relation to gout

AMS Ko, HP Tu, TT Liu, JG Chang, CY Yuo… - International journal …, 2013 - ncbi.nlm.nih.gov
Background The present study investigated whether single nucleotide polymorphisms
(SNPs) in the alpha-protein kinase 1 (ALPK1) gene are associated with gout in aboriginal …

[HTML][HTML] Common variant of ALPK1 is not associated with gout: a replication study

T Chiba, H Matsuo, M Sakiyama, A Nakayama… - Human Cell, 2015 - Springer
Gout is one of the most kinds of common inflammatory arthritis as a consequence of
hyperuricemia. Alpha-protein kinase 1 (ALPK1) gene locates in a gout-susceptibility locus …

[PDF][PDF] Associations of gout with polymorphisms in SLC2A9, WDR1, CLNK, PKD2, and ABCG2 in Chinese Han and Tibetan populations

Y Zhang, K Liu, L Ma, K Liu, X Shi, Y Zhang… - Int J Clin Exp Pathol …, 2016 - e-century.us
Gout is a common inflammatory arthritis triggered by the presence of monosodium urate
(MSU) crystals in joints and connective tissues. Current evidence suggests that heredity …

[HTML][HTML] Polymorphisms of ABCG2 and SLC22A12 Genes Associated with Gout Risk in Vietnamese Population

N Thuy Duong, N Thy Ngoc, N Tran Minh Thang… - Medicina, 2019 - mdpi.com
Background and objective: Gout is a common form of inflammatory arthritis caused by the
crystallization of uric acid. Previous studies have demonstrated that the genetic …

[HTML][HTML] Additive composite ABCG2, SLC2A9 and SLC22A12 scores of high-risk alleles with alcohol use modulate gout risk

HP Tu, CM Chung, A Min-Shan Ko, SS Lee… - Journal of human …, 2016 - nature.com
The aim of the present study was to evaluate the contribution of urate transporter genes and
alcohol use to the risk of gout/tophi. Eight variants of ABCG2, SLC2A9, SLC22A12 …

URAT1 inhibition by ALPK1 is associated with uric acid homeostasis

TM Kuo, CM Huang, HP Tu, A Min-Shan Ko… - …, 2017 - academic.oup.com
Objective. The aim of this study was to identify a protein for urate transporter 1 (URAT1)
regulation. Methods. The clinical dataset consisted of 492 case–control samples of Han …

[HTML][HTML] Polymorphisms in the presumptive promoter region of the SLC2A9 gene are associated with gout in a Chinese male population

C Li, N Chu, B Wang, J Wang, J Luan, L Han, D Meng… - PloS one, 2012 - journals.plos.org
Background Glucose transporter 9 (GLUT9) is a high-capacity/low-affinity urate transporter.
To date, several recent genome-wide association studies (GWAS) and follow-up studies …

[HTML][HTML] Genetic analysis of ABCG2 and SLC2A9 gene polymorphisms in gouty arthritis in a Korean population

YS Kim, Y Kim, G Park, SK Kim, JY Choe… - The Korean Journal …, 2015 - ncbi.nlm.nih.gov
Methods: We consecutively enrolled 109 patients with gout and 102 healthy controls. The
diagnosis of gout was based on the preliminary criteria of the America College of …

[HTML][HTML] A meta-analysis of the associations between the Q141K and Q126X ABCG2 gene variants and gout risk

R Li, L Miao, L Qin, Y Xiang, X Zhang… - … journal of clinical and …, 2015 - ncbi.nlm.nih.gov
Background: Gout is an inflammatory disease in which genetic factors play a role. ABCG2 is
a urate transporter, and the Q141K and Q126X variants of ABCG2 have been associated …