Systemic sclerosis (SSc) is a complex and incompletely understood disease associated with
fibrosis in multiple organs. Recent findings identify transforming growth factor-ß (TGF-ß), Wnt …

Abstract Systemic Sclerosis (SSc) is an autoimmune idiopathic connective tissue disease,
characterized by aberrant fibro-proliferative and inflammatory responses, causing fibrosis of …

Systemic sclerosis (SSc) is characterized by extensive fibrosis, vasculopathy and activation
of the immune system. Fibrosis can be caused by profibrotic cytokines, such as transforming …

Systemic sclerosis (SSc) is a chronic autoimmune disease with a high morbidity and
mortality. Skin and organ fibrosis are key manifestations of SSc, for which no generally …

Systemic sclerosis (SSc), an autoimmune disease that is associated with a number of
genetic and environmental risk factors, is characterized by progressive fibrosis and …

The aetiology of SSc is subject to ongoing research, as the precise events that underlie the
development of this disease remain unclear. The pathogenesis is known to involve …

Systemic sclerosis is an orphan connective tissue disease characterized by alterations of the
microvasculature, disturbances of the immune system and massive deposition of collagen …

Introduction‐Evidence for endothelial disease and loss of capillaries in SSc‐Angiogenesis
and vasculogenesis• Mechanisms and biomarkers of endothelial damage in SSc• …

Abstract Systemic sclerosis (scleroderma [SSc]) is a multifactorial disease characterized by
inflammation, extensive and progressive fibrosis, and multiple vasculopathies. The vascular …

Systemic sclerosis (SSc) is an acquired multiorgan connective tissue disease with variable
mortality and morbidity dictated by clinical subset type. The etiology of the basic disease and …