Fibrosis in systemic sclerosis: emerging concepts and implications for targeted therapy
Systemic sclerosis (SSc) is a complex and incompletely understood disease associated with
fibrosis in multiple organs. Recent findings identify transforming growth factor-ß (TGF-ß), Wnt …
fibrosis in multiple organs. Recent findings identify transforming growth factor-ß (TGF-ß), Wnt …
Bi-directional communication: Conversations between fibroblasts and immune cells in systemic sclerosis
JC Worrell, S O'Reilly - Journal of Autoimmunity, 2020 - Elsevier
Abstract Systemic Sclerosis (SSc) is an autoimmune idiopathic connective tissue disease,
characterized by aberrant fibro-proliferative and inflammatory responses, causing fibrosis of …
characterized by aberrant fibro-proliferative and inflammatory responses, causing fibrosis of …
New developments in the pathogenesis of systemic sclerosis
LI Sakkas - Autoimmunity, 2005 - Taylor & Francis
Systemic sclerosis (SSc) is characterized by extensive fibrosis, vasculopathy and activation
of the immune system. Fibrosis can be caused by profibrotic cytokines, such as transforming …
of the immune system. Fibrosis can be caused by profibrotic cytokines, such as transforming …
Systemic sclerosis and localized scleroderma—current concepts and novel targets for therapy
O Distler, A Cozzio - Seminars in immunopathology, 2016 - Springer
Systemic sclerosis (SSc) is a chronic autoimmune disease with a high morbidity and
mortality. Skin and organ fibrosis are key manifestations of SSc, for which no generally …
mortality. Skin and organ fibrosis are key manifestations of SSc, for which no generally …
A potential link between oxidative stress and endothelial-to-mesenchymal transition in systemic sclerosis
Systemic sclerosis (SSc), an autoimmune disease that is associated with a number of
genetic and environmental risk factors, is characterized by progressive fibrosis and …
genetic and environmental risk factors, is characterized by progressive fibrosis and …
Overview of pathogenesis of systemic sclerosis
DJ Abraham, T Krieg, J Distler, O Distler - Rheumatology, 2006 - academic.oup.com
The aetiology of SSc is subject to ongoing research, as the precise events that underlie the
development of this disease remain unclear. The pathogenesis is known to involve …
development of this disease remain unclear. The pathogenesis is known to involve …
Systemic sclerosis: recent insights
M Elhai, J Avouac, A Kahan, Y Allanore - Joint Bone Spine, 2015 - Elsevier
Systemic sclerosis is an orphan connective tissue disease characterized by alterations of the
microvasculature, disturbances of the immune system and massive deposition of collagen …
microvasculature, disturbances of the immune system and massive deposition of collagen …
Mechanisms in the loss of capillaries in systemic sclerosis: angiogenesis versus vasculogenesis
M Manetti, S Guiducci… - Journal of cellular …, 2010 - Wiley Online Library
Introduction‐Evidence for endothelial disease and loss of capillaries in SSc‐Angiogenesis
and vasculogenesis• Mechanisms and biomarkers of endothelial damage in SSc• …
and vasculogenesis• Mechanisms and biomarkers of endothelial damage in SSc• …
Angiogenesis and vasculopathy in systemic sclerosis: evolving concepts
BJ Rabquer, AE Koch - Current rheumatology reports, 2012 - Springer
Abstract Systemic sclerosis (scleroderma [SSc]) is a multifactorial disease characterized by
inflammation, extensive and progressive fibrosis, and multiple vasculopathies. The vascular …
inflammation, extensive and progressive fibrosis, and multiple vasculopathies. The vascular …
Vascular involvement in systemic sclerosis (scleroderma)
D Pattanaik, M Brown… - Journal of inflammation …, 2011 - Taylor & Francis
Systemic sclerosis (SSc) is an acquired multiorgan connective tissue disease with variable
mortality and morbidity dictated by clinical subset type. The etiology of the basic disease and …
mortality and morbidity dictated by clinical subset type. The etiology of the basic disease and …