Do infections facilitate the emergence of systemic sclerosis?
C Grossman, Z Dovrish, Y Shoenfeld, H Amital - Autoimmunity reviews, 2011 - Elsevier
Systemic sclerosis (SSc) is an autoimmune disease characterized by vascular obliteration,
excessive extracellular matrix deposition, and fibrosis of the connective tissues of the skin …
excessive extracellular matrix deposition, and fibrosis of the connective tissues of the skin …
Systemic sclerosis: an update in 2016
AC Desbois, P Cacoub - Autoimmunity reviews, 2016 - Elsevier
Systemic sclerosis (SSc) is a chronic immune disorder of unknown origin, dominated by
excessive fibrosis responsible for cutaneous and pulmonary fibrosis, and by vascular …
excessive fibrosis responsible for cutaneous and pulmonary fibrosis, and by vascular …
Immunopathogenesis of systemic sclerosis
B White - Rheumatic Disease Clinics, 1996 - rheumatic.theclinics.com
Over the last decade, it has become clear that an activated immune system plays a central
role in causing tissue damage in patients with systemic sclerosis (SSc). What remains …
role in causing tissue damage in patients with systemic sclerosis (SSc). What remains …
[PDF][PDF] Systemic sclerosis: from pathogenesis to targeted therapy
CP Denton - Clin Exp Rheumatol, 2015 - clinexprheumatol.org
Systemic sclerosis (scleroderma) leads to morbidity and mortality through a combination of
inflammation, fibrosis and vascular damage leading to internal organ complications affecting …
inflammation, fibrosis and vascular damage leading to internal organ complications affecting …
Contribution of monocytes and macrophages to the pathogenesis of systemic sclerosis: recent insights and therapeutic implications
A Lescoat, V Lecureur, J Varga - Current opinion in rheumatology, 2021 - journals.lww.com
Through their potential pro-fibrotic and pro-inflammatory properties, macrophages are at the
cross-road of key SSc pathogenic processes and associated manifestations. Investigative …
cross-road of key SSc pathogenic processes and associated manifestations. Investigative …
Systemic sclerosis: new evidence re-enforces the role of B cells
LI Sakkas, DP Bogdanos - Autoimmunity reviews, 2016 - Elsevier
Systemic sclerosis (SSc) is characterized by widespread fibrosis, microangiopathy
(vasospasms and stenosis), and formation of autoantibodies. T cell activation has been …
(vasospasms and stenosis), and formation of autoantibodies. T cell activation has been …
Frontiers of antifibrotic therapy in systemic sclerosis
JHW Distler, C Feghali‐Bostwick, A Soare… - Arthritis & …, 2017 - Wiley Online Library
Fibrosis is becoming increasingly recognized as a major cause of morbidity and mortality in
modern populations, yet still, no targeted antifibrotic therapies have been approved for most …
modern populations, yet still, no targeted antifibrotic therapies have been approved for most …
Relationship between cytokine profiles and clinical outcomes in patients with systemic sclerosis
J Baraut, L Michel, F Verrecchia, D Farge - Autoimmunity reviews, 2010 - Elsevier
Although the pathogenesis of systemic sclerosis (SSc) remains unknown, cytokine
production and release are key events in this autoimmune disease, characterized by T cell …
production and release are key events in this autoimmune disease, characterized by T cell …
Angiogenic cytokines and growth factors in systemic sclerosis
V Liakouli, P Cipriani, A Marrelli, S Alvaro, P Ruscitti… - Autoimmunity …, 2011 - Elsevier
Systemic sclerosis is an autoimmune connective tissue disorder characterized by a
widespread microangiopathy, autoimmunity and fibrosis of the skin and of various internal …
widespread microangiopathy, autoimmunity and fibrosis of the skin and of various internal …
Innate immunity in systemic sclerosis
C Dowson, N Simpson, L Duffy, S O'Reilly - Current rheumatology reports, 2017 - Springer
Abstract Purpose of Review Systemic sclerosis (SSc) is a heterogeneous autoimmune
disease which has defined three hallmarks: Small vessel vasculopathy, production of …
disease which has defined three hallmarks: Small vessel vasculopathy, production of …