Systemic sclerosis (SSc) is an autoimmune disease characterized by vascular obliteration,
excessive extracellular matrix deposition, and fibrosis of the connective tissues of the skin …

Systemic sclerosis (SSc) is a chronic immune disorder of unknown origin, dominated by
excessive fibrosis responsible for cutaneous and pulmonary fibrosis, and by vascular …

Over the last decade, it has become clear that an activated immune system plays a central
role in causing tissue damage in patients with systemic sclerosis (SSc). What remains …

Systemic sclerosis (scleroderma) leads to morbidity and mortality through a combination of
inflammation, fibrosis and vascular damage leading to internal organ complications affecting …

Through their potential pro-fibrotic and pro-inflammatory properties, macrophages are at the
cross-road of key SSc pathogenic processes and associated manifestations. Investigative …

Systemic sclerosis (SSc) is characterized by widespread fibrosis, microangiopathy
(vasospasms and stenosis), and formation of autoantibodies. T cell activation has been …

Fibrosis is becoming increasingly recognized as a major cause of morbidity and mortality in
modern populations, yet still, no targeted antifibrotic therapies have been approved for most …

Although the pathogenesis of systemic sclerosis (SSc) remains unknown, cytokine
production and release are key events in this autoimmune disease, characterized by T cell …

Systemic sclerosis is an autoimmune connective tissue disorder characterized by a
widespread microangiopathy, autoimmunity and fibrosis of the skin and of various internal …

Abstract Purpose of Review Systemic sclerosis (SSc) is a heterogeneous autoimmune
disease which has defined three hallmarks: Small vessel vasculopathy, production of …