As the amount of biological data in the public domain grows, so does the range of modeling
and analysis techniques employed in systems biology. In recent years, a number of …

The last several decades have witnessed a vast accumulation of biological data and data
analysis. Many of these data sets represent only a small fraction of the system's behavior …

Computational modeling of biological systems is becoming increasingly important in efforts
to better understand complex biological behaviors. In this review, we distinguish between …

What is systems biology if all definitions of biology implicitly or explicitly refer to the study of a
whole object, whether it is a virus, a cell, a bacterium, a protozoan or a metazoan? We treat …

What is systems biology if all definitions of biology implicitly or explicitly refer to the study of a
whole object, whether it is a virus, a cell, a bacterium, a protozoan or a metazoan? We treat …

We present a Systems Biology Toolbox for the widely used general purpose mathematical
software MATLAB. The toolbox offers systems biologists an open and extensible …

Biochemical systems biology augments more traditional disciplines, such as genomics,
biochemistry and molecular biology, by championing (i) mathematical and computational …

A central claim of computational systems biology is that, by drawing on mathematical
approaches developed in the context of dynamic systems, kinetic analysis, computational …

Mathematical and computational models are increasingly used to help interpret biomedical
data produced by high-throughput genomics and proteomics projects. The application of …

Abstract Systems biology represents an experimental approach to biology that attempts to
study biological systems in a holistic rather than an atomistic manner. Ideally this involves …