A multicenter phase IIb study of a novel combination of intramuscular androgen (testosterone decanoate) and oral progestogen (etonogestrel) for male hormonal …

CJ Hay, BM Brady, M Zitzmann… - The Journal of …, 2005 - academic.oup.com
The effect of a novel combination of oral etonogestrel (ENG) and im testosterone decanoate
(TD) on suppression of gonadotropins and spermatogenesis as a potential lead for male …

An effective hormonal male contraceptive using testosterone undecanoate with oral or injectable norethisterone preparations

A Kamischke, T Heuermann, K Krüger… - The Journal of …, 2002 - academic.oup.com
Suppression of spermatogenesis to azoospermia is the goal of hormonal male contraception
based on T combined with gestagens. The combination of the long-acting T, ester …

Intramuscular testosterone undecanoate and norethisterone enanthate in a clinical trial for male contraception

A Kamischke, S Venherm, D Plöger… - The Journal of …, 2001 - academic.oup.com
Recent trials for hormonal male contraception are based on gestagens or GnRH antagonists
combined with oral or injectable testosterone substitution. However, the efficacy of most …

Clinical trials in male hormonal contraception

E Nieschlag - Contraception, 2010 - Elsevier
Research has established the principle of hormonal male contraception based on
suppression of gonadotropins and spermatogenesis. All hormonal male contraceptives use …

Dose-finding study of oral desogestrel with testosterone pellets for suppression of the pituitary–testicular axis in normal men

CW Martin, SC Riley, D Everington… - Human …, 2000 - academic.oup.com
Prototype hormonal male contraceptive regimens generally achieve only incomplete
suppression to azoospermia with potentially adverse metabolic effects. We have carried out …

Male contraception: clinical assessment of chronic administration of testosterone enanthate

RS Swerdloff, A Palacios, RD McClure… - … journal of andrology, 1978 - Wiley Online Library
Testosterone enanthate (TE) was administered im to 39 normal adult men (age 21–39) to
assess its efficacy as a suppressor of spermatogeneis and to determine possible adverse …

Intramuscular testosterone undecanoate with or without oral levonorgestrel: a randomized placebo‐controlled feasability study for male contraception

A Kamischke, D PloÈger, S Venherm… - Clinical …, 2000 - Wiley Online Library
OBJECTIVE Approaches to hormonal male contraception are based on injectable
testosterone esters alone or in combination with gestagens or GnRH analogs but the short …

Male hormonal contraception

E Nieschlag - Fertility Control, 2010 - Springer
The principle of hormonal male contraception based on suppression of gonadotropins and
spermatogenesis has been established over the last three decades. All hormonal male …

Comparison between testosterone enanthate-induced azoospermia and oligozoospermia in a male contraceptive study. II. Pharmacokinetics and pharmacodynamics …

RA Anderson, FC Wu - The Journal of Clinical Endocrinology & …, 1996 - academic.oup.com
Hormonal suppression of spermatogenesis is currently being investigated as a method of
reversible male contraception. However, administration of exogenous testosterone (T) …

Combined administration of levonorgestrel and testosterone induces more rapid and effective suppression of spermatogenesis than testosterone alone: a promising …

RA Bebb, BD Anawalt, RB Christensen… - The Journal of …, 1996 - academic.oup.com
Studies using high dose testosterone (T) administration in normal men as a male
contraceptive have resulted in azoospermia rates of only 50-70%. Previous studies of T and …