Oxidative stress, defined as an excess production of reactive oxygen species (ROS) relative
to antioxidant defense, has been shown to play an important role in the pathophysiology of …

Despite advances in treatment, chronic congestive heart failure carries a poor prognosis and
remains a leading cause of cardiovascular death. Accumulating evidence suggests that …

Heart failure and many of the conditions that predispose to heart failure are associated with
oxidative stress. This is considered to be important in the pathophysiology of the condition …

Substantial evidence suggests the involvement of oxidative stress in the pathophysiology of
congestive heart failure and its antecedent conditions such as cardiac hypertrophy and …

Reactive oxygen species (ROS) are subcellular messengers in gene regulatory and signal
transduction pathways. In pathological situations, ROS accumulate due to excessive …

Background: A common phenotype associated with heart failure is the development of
cardiac hypertrophy. Cardiac hypertrophy occurs in response to stress, such as …

Over the past several decades, investigations in humans and animal models of heart failure
(HF) have provided substantial evidence that oxidative stress is increased in HF and …

Systolic and diastolic myocardial dysfunction has been demonstrated to be associated with
an activation of the circulating and local renin–angiotensin–aldosterone system (RAAS), and …

Heart failure is characterized by neurohumoral alterations, such as activation of the
sympathetic nervous system, stimulation of the renin-angiotensin system, increased activity …

Heart failure is a growing health burden worldwide characterized by alterations in excitation-
contraction coupling, cardiac energetic deficit and oxidative stress. While current treatments …