The concept of utilizing localized radiation therapy to elicit out-of-target tumor responses—
the abscopal effect—was proposed over 50 years ago (1, 2). Over the past decades, the …

The abscopal effect is mediated by a systemic anti-tumor immune response and reflects the
regression of non-irradiated metastatic lesions at a distance from the primary site of …

Radiotherapy has been used for more than a hundred years to cure or locally control tumors.
Regression of tumors outside of the irradiated field was occasionally observed and is known …

Mounting evidence suggests that radiation stimulates the immune system and this
contributes to the abscopal effect, which is defined as “response at a distance from the …

The abscopal effect is a systemic immune response mediated by the effects of radiation on
the immune system. This effect has been observed in a number of cancer types in addition to …

For over a century, ionising radiation has been used to treat cancer based on its cytotoxic
effects on tumour cells. Technical progress has enabled more precise targeting of the …

The combination of radiation and immunotherapy is currently an exciting avenue of pre-
clinical and clinical investigation. The synergy between these two treatment modalities has …

Radiation therapy (RT) is a cornerstone in oncologic management and is employed in
various curative and palliative scenarios for local-regional control. RT is thought to locally …

An 'abscopal'effect if often used to refer to distant tumour regression after localised
irradiation. Since the first report of the abscopal effect in the 1950s, well-documented cases …

Background Recently, immunologic responses to localized irradiation are proposed as
mediator of systemic effects after localized radiotherapy (called the abscopal effect). Here …