CD44 suppresses TLR-mediated inflammation
H Kawana, H Karaki, M Higashi, M Miyazaki… - The Journal of …, 2008 - journals.aai.org
The cell adhesion molecule CD44, which is the major hyaluronan receptor, has been
implicated in the binding, endocytosis, and metabolism of hyaluronan. Previous studies …
implicated in the binding, endocytosis, and metabolism of hyaluronan. Previous studies …
Differential use of chondroitin sulfate to regulate hyaluronan binding by receptor CD44 in inflammatory and interleukin 4-activated macrophages
B Ruffell, GFT Poon, SSM Lee, KL Brown… - Journal of Biological …, 2011 - ASBMB
CD44 is a cell surface receptor for the extracellular matrix glycosaminoglycan hyaluronan
and is involved in processes ranging from leukocyte recruitment to wound healing. In the …
and is involved in processes ranging from leukocyte recruitment to wound healing. In the …
Role of CD44 in regulating TLR2 activation of human macrophages and downstream expression of proinflammatory cytokines
Osteoarthritis (OA) is a low-grade chronic inflammatory joint disease. Innate immunity
contributes to OA progression, mediated by TLR2 and TLR4. We evaluated the role of …
contributes to OA progression, mediated by TLR2 and TLR4. We evaluated the role of …
A crucial role for CD44 in inflammation
E Puré, CA Cuff - Trends in molecular medicine, 2001 - cell.com
Current therapies for chronic inflammatory diseases typically act through the nonspecific
downregulation of immune cell activation. However, it is becoming increasingly evident that …
downregulation of immune cell activation. However, it is becoming increasingly evident that …
CD44 is a negative regulator of acute pulmonary inflammation and lipopolysaccharide-TLR signaling in mouse macrophages
CD44 is a transmembrane adhesion molecule and hemopoietic CD44 has an essential role
in hyaluronan clearance and resolution of noninfectious lung injury. In this study, we …
in hyaluronan clearance and resolution of noninfectious lung injury. In this study, we …
CD44 differentially activates mouse NK T cells and conventional T cells
Abstract NK T (NKT) cells are an important component of the innate immune system and
recognize the MHC class I-like CD1d molecule. NKT cells possess significant …
recognize the MHC class I-like CD1d molecule. NKT cells possess significant …
Tumor necrosis factor-α induces functionally active hyaluronan-adhesive CD44 by activating sialidase through p38 mitogen-activated protein kinase in …
Interaction of CD44, an adhesion molecule, with its ligand, hyaluronan (HA), in monocytic
cells plays a critical role in cell migration, inflammation, and immune responses. Most cell …
cells plays a critical role in cell migration, inflammation, and immune responses. Most cell …
CD44 signaling through p56lck involves lateral association with CD4 in human CD4+ T cells
U Dianzani, M Bragardo, A Tosti… - International …, 1999 - academic.oup.com
CD44 is a family of mucin-like membrane proteins generated by alternative splicing of
several exons, and participate in T cell adhesion and activation. CD44-mediated signaling …
several exons, and participate in T cell adhesion and activation. CD44-mediated signaling …
CD44 and its role in inflammation and inflammatory diseases
The cell adhesion molecule CD44 is expressed on the majority of immune cells and is
responsible for mediating adhesion to the extracellular matrix glycosaminoglycan …
responsible for mediating adhesion to the extracellular matrix glycosaminoglycan …
CD44 plays a co-stimulatory role in murine T cell activation: ligation of CD44 selectively co-stimulates IL-2 production, but not proliferation in TCR-stimulated murine …
F Sommer, M Huber, M Röllinghoff… - International …, 1995 - academic.oup.com
The murine CD44 receptor family is thought to be involved in a variety of lymphocyte
functions, including lymphopoesis, lymphocyte homing and cell migration. Herein, we show …
functions, including lymphopoesis, lymphocyte homing and cell migration. Herein, we show …