Abstract In 1983 Jan V. Bokhman, MD published a landmark paper entitled “Two
Pathogenetic Types of Endometrial Carcinoma” in which an enduring dualistic view of …

Purpose Endometrial cancers have long been divided into estrogen-dependent type I and
the less common clinically aggressive estrogen-independent type II. Little is known about …

Introduction Many advances in the understanding of the pathologic and molecular features
of endometrial cancer have occurred since the FIGO staging was last updated in 2009 …

OBJECTIVE: Although the epidemiology of typical endometrial carcinomas (grades 1–2
endometrioid or Type I) is well established, less is known regarding higher grade …

Endometrial cancer is a clinically heterogeneous disease and it is becoming increasingly
clear that this heterogeneity may be a function of the diversity of the underlying molecular …

Endometrial carcinoma (EC) is the fourth most common cancer in women in the developed
world. Classification of ECs by histomorphologic criteria has limited reproducibility and …

Endometrial carcinoma is the most common gynecologic cancer in developed nations, and
the annual incidence is projected to increase, secondary to the high prevalence of obesity, a …

Following the discovery of the four molecular subtypes of endometrial cancer (EC) by The
Cancer Genome Atlas (TCGA) in 2013, subsequent studies used surrogate markers to …

BACKGROUND Classification of endometrial carcinomas (ECs) by morphologic features is
irreproducible and imperfectly reflects tumor biology. The authors developed the Proactive …

Endometrial cancers are the most common gynecologic malignancies. The staging of
endometrial cancer has evolved from a clinical-based system to a comprehensive surgical …