Reduced in vitro functional activity of human NRAMP1 (SLC11A1) allele that predisposes to increased risk of pediatric tuberculosis disease

CJ Gallant, S Malik, N Jabado, M Cellier, L Simkin… - Genes & …, 2007 - nature.com
Polymorphic variants within the human natural resistance-associated macrophage protein-1
(NRAMP1, also known as SLC11A1) gene have been shown to impact on susceptibility to …

[PDF][PDF] NRAMP1/SLC11A1 gene polymorphisms and host susceptibility to Mycobacterium tuberculosis and M. leprae in South Sulawesi, Indonesia

M Hatta, TM Ratnawati, J Ito, T Shirakawa… - Southeast Asian J …, 2010 - academia.edu
Genetic host factor may play an important role in controlling mycobacterial infections such as
tuberculosis and leprosy. Natural resistance associated macrophage protein1 (Nramp1 …

Variants of the Natural Resistance-Associated Macrophage Protein 1 Gene (NRAMP1) Are Associated with Severe Forms of Pulmonary Tuberculosis

W Zhang, L Shao, X Weng, Z Hu, A Jin… - Clinical infectious …, 2005 - academic.oup.com
Although genetic factors may affect susceptibility to tuberculosis, studies that have assessed
variants of the natural resistance-associated macrophage protein 1 gene (NRAMP1) and …

NRAMP1 and susceptibility to tuberculosis

R Bellamy - The International Journal of Tuberculosis and Lung …, 2002 - ingentaconnect.com
OVER TWENTY YEARS AGO it was recognised that among inbred strains of mice, innate
susceptibility/resistance to the early phase of infection with Mycobacterium bovis (BCG) was …

Ethnic-specific genetic associations with pulmonary tuberculosis

JC Delgado, A Baena, S Thim… - The Journal of infectious …, 2002 - academic.oup.com
Several susceptibility-associated genetic polymorphisms have been proposed to explain
differential susceptibility to tuberculosis (TB) disease progression in different populations …

[HTML][HTML] The NRAMP1 polymorphism as a risk factor for tuberculous spondylitis

B Tiksnadi, H Herman - Malaysian orthopaedic journal, 2013 - ncbi.nlm.nih.gov
In the present study, we analysed the association between the incidence of tuberculous
spondylitis with the Natural Resistance Associated Macrophage Protein 1 (NRAMP1, also …

SLC11A1 (formerly NRAMP1) polymorphisms associated with multidrug-resistant tuberculosis

K Takahashi, Y Hasegawa, T Abe, T Yamamoto… - Tuberculosis, 2008 - Elsevier
The solute carrier family 11 member 1 gene (SLC11A1, formerly known as NRAMP1: natural
resistance-associated macrophage protein 1) is one of the host genetic factors reported to …

Alleles of the NRAMP1 gene are risk factors for pediatric tuberculosis disease

S Malik, L Abel, H Tooker, A Poon… - Proceedings of the …, 2005 - National Acad Sciences
Relatively little is known about the human genetics of susceptibility to common diseases
caused by bacterial pathogens. Tuberculosis, caused by Mycobacterium tuberculosis, is a …

NRAMP1 (SLC11A1) gene polymorphisms that correlate with autoimmune versus infectious disease susceptibility in tuberculosis and rheumatoid arthritis

Ö Ates, L Dalyan, B Müsellim, G Hatemi… - International journal …, 2009 - Wiley Online Library
NRAMP1 gene has multiple pleiotropic effects on macrophage activation pathways. These
pleiotropic effects may increase resistance to infections such as tuberculosis (TB), but may …

A case-control study on natural-resistance-associated macrophage protein 1 gene polymorphisms and susceptibility to pulmonary tuberculosis

W Liu, CY Zhang, L Tian, CZ Li, XM Wu… - … yu Fang yi xue za zhi …, 2003 - europepmc.org
OBJECTIVE: To investigate association between the natural-resistance-associated
macrophage protein 1 (NRAMP1) gene polymorphisms and susceptibility to pulmonary …