Chemokine levels and chemokine receptor expression in the blood and the cerebrospinal fluid of HIV-infected patients with cryptococcal meningitis and …

CC Chang, S Omarjee, A Lim, T Spelman… - The Journal of …, 2013 - academic.oup.com
Background. Human immunodeficiency virus–infected patients with treated cryptococcal
meningitis who start combination antiretroviral therapy (cART) are at risk of further …

Cryptococcosis-IRIS is Associated With Lower Cryptococcus-specific IFN-γ Responses Before Antiretroviral Therapy but Not Higher T-Cell Responses During …

CC Chang, A Lim, S Omarjee, SM Levitz… - The Journal of …, 2013 - academic.oup.com
Background. Cryptococcosis-associated immune reconstitution inflammatory syndrome (C-
IRIS) may be driven by aberrant T-cell responses against cryptococci. We investigated this in …

Plasma but not cerebrospinal fluid interleukin 7 and interleukin 5 levels pre–antiretroviral therapy commencement predict cryptococcosis-associated immune …

NA Akilimali, CC Chang, DM Muema… - Clinical Infectious …, 2017 - academic.oup.com
Background Patients with human immunodeficiency virus/AIDS-associated cryptococcal
meningitis (CM) frequently experience clinical deterioration, known as cryptococcosis …

Paucity of initial cerebrospinal fluid inflammation in cryptococcal meningitis is associated with subsequent immune reconstitution inflammatory syndrome

DR Boulware, SC Bonham, DB Meya… - The Journal of …, 2010 - academic.oup.com
Abstract Background. Cryptococcal meningitis (CM)-related immune reconstitution
inflammatory syndrome (IRIS) complicates antiretroviral therapy (ART) in 20%–40% of ART …

Cellular immune activation in cerebrospinal fluid from Ugandans with cryptococcal meningitis and immune reconstitution inflammatory syndrome

DB Meya, S Okurut, G Zziwa, MA Rolfes… - The Journal of …, 2015 - academic.oup.com
Background. Human immunodeficiency virus (HIV)-associated cryptococcal meningitis (CM)
is characterized by high fungal burden and limited leukocyte trafficking to cerebrospinal fluid …

Hiv-associated cryptococcal immune reconstitution inflammatory syndrome is associated with aberrant t cell function and increased cytokine responses

DB Meya, S Okurut, G Zziwa, S Cose, DR Boulware… - Journal of Fungi, 2019 - mdpi.com
Cryptococcal meningitis remains a significant opportunistic infection among HIV-infected
patients, contributing 15–20% of HIV-related mortality. A complication of initiating …

Cerebrospinal fluid cytokine profiles predict risk of early mortality and immune reconstitution inflammatory syndrome in HIV-associated cryptococcal meningitis

JN Jarvis, G Meintjes, T Bicanic, V Buffa… - PLoS …, 2015 - journals.plos.org
Understanding the host immune response during cryptococcal meningitis (CM) is of critical
importance for the development of immunomodulatory therapies. We profiled the …

Clinical and mycological predictors of cryptococcosis-associated immune reconstitution inflammatory syndrome

CC Chang, AA Dorasamy, BI Gosnell, JH Elliott… - Aids, 2013 - journals.lww.com
Objective: HIV-infected patients with treated cryptococcal meningitis are at risk for further
neurological deterioration after commencing combination antiretroviral therapy (cART) …

Association Between Plasma Antibody Responses and Risk for Cryptococcus-Associated Immune Reconstitution Inflammatory Syndrome

HA Yoon, A Nakouzi, CC Chang… - The Journal of …, 2019 - academic.oup.com
Background Initiation of antiretroviral therapy (ART) in human immunodeficiency virus (HIV)-
infected individuals with cryptococcal meningitis places them at risk for Cryptococcus …

Clinical features and serum biomarkers in HIV immune reconstitution inflammatory syndrome after cryptococcal meningitis: a prospective cohort study

DR Boulware, DB Meya, TL Bergemann… - PLoS …, 2010 - journals.plos.org
Background Although antiretroviral therapy (ART) improves survival in persons with
cryptococcal meningitis (CM) and AIDS, ART frequently elicits HIV immune reconstitution …