Chondroitin sulphate proteoglycans (CSPGs) are up‐regulated in the CNS after injury and
inhibit axon regeneration mainly through their glycosaminoglycan (CS‐GAG) chains. We …

Chondroitin sulfate proteoglycans (CSPGs) are upregulated in the CNS after injury and
participate in the inhibition of axon regeneration mainly through their glycosaminoglycan …

Chondroitin sulphate proteoglycans (CSPGs) upregulated in the glial scar inhibit axon
regeneration via their sulphated glycosaminoglycans (GAGs). Chondroitin 6 …

Chondroitin sulfate proteoglycans (CSPGs) play a pivotal role in many neuronal growth
mechanisms including axon guidance and the modulation of repair processes following …

After injury to the adult central nervous system (CNS), numerous cytokines and growth
factors are released that contribute to reactive gliosis and extracellular matrix production. In …

Chondroitin sulphate proteoglycans (CSPGs) are a family of inhibitory extracellular matrix
molecules that are highly expressed during development, where they are involved in …

Traumatic spinal cord injury produces long-term neurological damage, and presents a
significant public health problem with nearly 18,000 new cases per year in the US The injury …

In response to injury to the central nervous system (CNS), reactive astrocytes appear and
accumulate in the wounded area, leading to glial scar formation. Glial scar is the physical …

CNS damage often results in demyelination of spared axons due to oligodendroglial cell
death and dysfunction near the injury site. Although new oligodendroglia are generated …

Several extracellular matrix (ECM) molecules have been identified as potent inhibitors of
neurite outgrowth in vitro and are believed to limit axonal growth after CNS injury. Recent …