Blood vessels supply developing organs with metabolic sustenance. Here, we demonstrate
a role for blood vessels as a source of developmental signals during pancreatic …

The embryonic role of endothelial cells and nascent vessels in promoting organogenesis,
prior to vascular function, is unclear. We find that early endothelial cells in mouse embryos …

How organ size and form are controlled during development is a major question in biology.
Blood vessels have been shown to be essential for early development of the liver and …

Blood vessels course through organs, providing them with essential nutrient and gaseous
exchange. However, the vasculature has also been shown to provide non-nutritional signals …

Although the source of embryonic stem (ES) cells presents ethical concerns, their use may
lead to many clinical benefits if differentiated cell types can be derived from them and used …

The postnatal coronary vessels have been viewed as developing through expansion of
vessels formed during the fetal period. Using genetic lineage tracing, we found that a …

Metabolic regulation in mammals requires communication between multiple organs and
tissues. The rise in the incidence of obesity and associated metabolic disorders, including …

Studies of the formation of pancreas and liver progenitors have focused on individual
inductive signals and cellular responses. Here, we investigated how bone morphogenetic …

The pancreas originates from two epithelial evaginations of the foregut, which consist of
multipotent epithelial progenitors that organize into a complex tubular epithelial network …

Blood vessel endothelium has been recently shown to induce endocrine pancreatic
development [1]. Because pancreatic endocrine cells or islets express high levels of …