T cells dynamically interact with multiple, distinct cellular subsets to determine effector and
memory differentiation. Here, we developed a platform to quantify cell location in three …

After an infection, the immune system generates long-lived memory lymphocytes whose
increased frequency and altered state of differentiation enhance host defense against …

The pathways for differentiation of human CD4+ T cells into functionally distinct subsets of
memory cells in vivo are unknown. The identification of these subsets and pathways has …

Central memory CD8+ T cells (TCM) confer superior protective immunity against infections
compared with other T cell subsets. TCM recirculate mainly through secondary lymphoid …

Strength of inflammatory stimuli during the early expansion phase plays a crucial role in the
effector versus memory cell fate decision of CD8+ T cells. But it is not known how early …

Bystander activation of memory T cells occurs in the absence of cognate antigen during
infections that elicit strong systemic inflammatory responses, which subsequently affect host …

A defining feature of vertebrate immunity is the acquisition of immunological memory, which
confers enhanced protection against pathogens by mechanisms that are incompletely …

Tissue-resident memory (TRM) CD8+ T cells are largely derived from recently activated
effector T cells, but the mechanisms that control the extent of TRM differentiation within …

Generation of a robust immunological memory response is essential for protection on
subsequent encounters with the same pathogen. The magnitude and quality of the memory …

Infections induce pathogen-specific T cell differentiation into diverse effectors (Teff) that give
rise to memory (Tmem) subsets. The cell-fate decisions and lineage relationships that …