Background Bronchial asthma (BA) is a chronic disease of the airways. The great majority of
BA exacerbations are associated with respiratory viral infections. Recent findings point out a …

Background Rhinovirus infection triggers acute asthma exacerbations. IL-33 is an instructive
cytokine of type 2 inflammation whose expression is associated with viral load during …

Background Respiratory viral infections are one of the leading causes of need for
emergency care and hospitalizations in asthmatic individuals, and airway-secreted …

Rationale: Rhinoviruses are the major cause of asthma exacerbations; however, its
underlying mechanisms are poorly understood. We hypothesized that the epithelial cell …

Background Bronchial smooth muscle cells (BSMCs) from severe asthmatics have been
shown to overexpress the Th2-driving and asthma-associated cytokine IL-33. However, little …

Background Asthma exacerbations are commonly associated with rhinovirus (RV) infection.
Interleukin-33 (IL-33) plays an important role during exacerbation by enhancing Type 2 …

Interleukin-33 (IL-33) is an epithelial-derived cytokine that initiates type 2 immune responses
to allergens, though whether IL-33 has the ability to modify responses to respiratory viral …

Background Influenza virus triggers severe asthma exacerbations for which no adequate
treatment is available. It is known that IL-33 levels correlate with exacerbation severity, but …

Abstract Interleukin 33 (IL-33) represents a potential link between the airway epithelium and
induction of Th2-type inflammatory responses associated with the development of asthma …

Background Frequent viral lower respiratory infections in early life are an independent risk
factor for asthma onset. This risk and the development of persistent asthma are significantly …